Human Campylobacter spp. infections in Italy

Verena Zerbato; Stefano Di Bella; Riccardo Pol; Roberto Luzzati; Gianfranco Sanson; Simone Ambretti; Stefano Andreoni; Richard Aschbacher; Mariano Bernardo; Alessandra Bielli; Gioconda Brigante; Marina Busetti; Giulio Camarlinghi; Davide Carcione; Antonella Carducci; Nicola Clementi; Edoardo Carretto; Chiara Chilleri; Giulia Codda; Alessandra Consonni; Venera Costantino; Venere Cortazzo; Manuela Di Santolo; Saveria Dodaro; Barbara Fiori; Aurora García-Fernández; Claudio Foschi; Elisa Gobbato; Francesca Greco; Roberto Marcello La Ragione; Nicasio Mancini; Alberto Enrico Maraolo; Anna Marchese; Daniela Marcuccio; Roberta Marrollo; Carola Mauri; Annarita Mazzariol; Gianluca Morroni; Adriana Mosca; Giacomo Nigrisoli . Elisabetta Pagani; Eva Maria Parisio; Simona Pollini; Mario Sarti; Annarita Sorrentino; Domenico Trotta; Laura Villa; Chiara Vismara; Luigi Principe

doi:10.1007/s10096-024-04803-0

Human Campylobacter spp. infections in Italy

Verena Zerbato^*, Stefano Di Bella, Riccardo Pol, Roberto Luzzati, Gianfranco Sanson, Simone Ambretti, Stefano Andreoni, Richard Aschbacher, Mariano Bernardo, Alessandra Bielli, Gioconda Brigante, Marina Busetti, Giulio Camarlinghi, Davide Carcione, Antonella Carducci, Nicola Clementi, Edoardo Carretto, Chiara Chilleri, Giulia Codda, Alessandra ConsonniVenera Costantino, Venere Cortazzo, Manuela Di Santolo, Saveria Dodaro, Barbara Fiori, Aurora García-Fernández, Claudio Foschi, Elisa Gobbato, Francesca Greco, Roberto Marcello La Ragione, Nicasio Mancini, Alberto Enrico Maraolo, Anna Marchese, Daniela Marcuccio, Roberta Marrollo, Carola Mauri, Annarita Mazzariol, Gianluca Morroni, Adriana Mosca, Giacomo Nigrisoli . Elisabetta Pagani, Eva Maria Parisio, Simona Pollini, Mario Sarti, Annarita Sorrentino, Domenico Trotta, Laura Villa, Chiara Vismara, Luigi Principe

^*Corresponding author

Research output: Contribution to journal › Article

Abstract

Purpose\r\n\r\nCampylobacter is a frequent cause of enteric infections with common antimicrobial resistance issues. The most recent reports of campylobacteriosis in Italy include data from 2013 to 2016. We aimed to provide national epidemiological and microbiological data on human Campylobacter infections in Italy during the period 2017–2021.\r\nMethods\r\n\r\nData was collected from 19 Hospitals in 13 Italian Regions. Bacterial identification was performed by mass spectrometry. Antibiograms were determined with Etest or Kirby-Bauer (EUCAST criteria).\r\nResults\r\n\r\nIn total, 5419 isolations of Campylobacter spp. were performed. The most common species were C. jejuni (n = 4535, 83.7%), followed by C. coli (n = 732, 13.5%) and C. fetus (n = 34, 0.6%). The mean age of patients was 34.61 years and 57.1% were males. Outpatients accounted for 54% of the cases detected. Campylobacter were isolated from faeces in 97.3% of cases and in 2.7% from blood. C. fetus was mostly isolated from blood (88.2% of cases). We tested for antimicrobial susceptibility 4627 isolates (85.4%). Resistance to ciprofloxacin and tetracyclines was 75.5% and 54.8%, respectively; resistance to erythromycin was 4.8%; clarithromycin 2% and azithromycin 2%. 50% of C. jejuni and C. coli were resistant to ≥ 2 antibiotics. Over the study period, resistance to ciprofloxacin and tetracyclines significantly decreased (p < 0.005), while resistance to macrolides remained stable.\r\nConclusion\r\n\r\nCampylobacter resistance to fluoroquinolones and tetracyclines in Italy is decreasing but is still high, while macrolides retain good activity.

Original language	English
Pages (from-to)	895-904
Number of pages	10
Journal	European Journal of Clinical Microbiological Infectious Diseases
Volume	43
Issue number	5
DOIs	https://doi.org/10.1007/s10096-024-04803-0
Publication status	Published - 2024
Externally published	Yes

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases

Keywords

Campylobacter spp

Access to Document

10.1007/s10096-024-04803-0

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Zerbato, V., Bella, S. D., Pol, R., Luzzati, R., Sanson, G., Ambretti, S., Andreoni, S., Aschbacher, R., Bernardo, M., Bielli, A., Brigante, G., Busetti, M., Camarlinghi, G., Carcione, D., Carducci, A., Clementi, N., Carretto, E., Chilleri, C., Codda, G., ... Principe, L. (2024). Human Campylobacter spp. infections in Italy. European Journal of Clinical Microbiological Infectious Diseases, 43(5), 895-904. https://doi.org/10.1007/s10096-024-04803-0

@article{de5609eb43024ad296f46a702631d216,

title = "Human Campylobacter spp. infections in Italy",

abstract = "Purpose\r\n\r\nCampylobacter is a frequent cause of enteric infections with common antimicrobial resistance issues. The most recent reports of campylobacteriosis in Italy include data from 2013 to 2016. We aimed to provide national epidemiological and microbiological data on human Campylobacter infections in Italy during the period 2017–2021.\r\nMethods\r\n\r\nData was collected from 19 Hospitals in 13 Italian Regions. Bacterial identification was performed by mass spectrometry. Antibiograms were determined with Etest or Kirby-Bauer (EUCAST criteria).\r\nResults\r\n\r\nIn total, 5419 isolations of Campylobacter spp. were performed. The most common species were C. jejuni (n = 4535, 83.7%), followed by C. coli (n = 732, 13.5%) and C. fetus (n = 34, 0.6%). The mean age of patients was 34.61 years and 57.1% were males. Outpatients accounted for 54% of the cases detected. Campylobacter were isolated from faeces in 97.3% of cases and in 2.7% from blood. C. fetus was mostly isolated from blood (88.2% of cases). We tested for antimicrobial susceptibility 4627 isolates (85.4%). Resistance to ciprofloxacin and tetracyclines was 75.5% and 54.8%, respectively; resistance to erythromycin was 4.8%; clarithromycin 2% and azithromycin 2%. 50% of C. jejuni and C. coli were resistant to ≥ 2 antibiotics. Over the study period, resistance to ciprofloxacin and tetracyclines significantly decreased (p < 0.005), while resistance to macrolides remained stable.\r\nConclusion\r\n\r\nCampylobacter resistance to fluoroquinolones and tetracyclines in Italy is decreasing but is still high, while macrolides retain good activity.",

keywords = "Campylobacter spp, Campylobacter spp",

author = "Verena Zerbato and Bella, {Stefano Di} and Riccardo Pol and Roberto Luzzati and Gianfranco Sanson and Simone Ambretti and Stefano Andreoni and Richard Aschbacher and Mariano Bernardo and Alessandra Bielli and Gioconda Brigante and Marina Busetti and Giulio Camarlinghi and Davide Carcione and Antonella Carducci and Nicola Clementi and Edoardo Carretto and Chiara Chilleri and Giulia Codda and Alessandra Consonni and Venera Costantino and Venere Cortazzo and Santolo, {Manuela Di} and Saveria Dodaro and Barbara Fiori and Aurora Garc{\'i}a-Fern{\'a}ndez and Claudio Foschi and Elisa Gobbato and Francesca Greco and Ragione, {Roberto Marcello La} and Nicasio Mancini and Maraolo, {Alberto Enrico} and Anna Marchese and Daniela Marcuccio and Roberta Marrollo and Carola Mauri and Annarita Mazzariol and Gianluca Morroni and Adriana Mosca and Pagani, {Giacomo Nigrisoli . Elisabetta} and Parisio, {Eva Maria} and Simona Pollini and Mario Sarti and Annarita Sorrentino and Domenico Trotta and Laura Villa and Chiara Vismara and Luigi Principe",

year = "2024",

doi = "10.1007/s10096-024-04803-0",

language = "English",

volume = "43",

pages = "895--904",

journal = "European Journal of Clinical Microbiological Infectious Diseases",

number = "5",

}

Zerbato, V, Bella, SD, Pol, R, Luzzati, R, Sanson, G, Ambretti, S, Andreoni, S, Aschbacher, R, Bernardo, M, Bielli, A, Brigante, G, Busetti, M, Camarlinghi, G, Carcione, D, Carducci, A, Clementi, N, Carretto, E, Chilleri, C, Codda, G, Consonni, A, Costantino, V, Cortazzo, V, Santolo, MD, Dodaro, S, Fiori, B, García-Fernández, A, Foschi, C, Gobbato, E, Greco, F, Ragione, RML, Mancini, N, Maraolo, AE, Marchese, A, Marcuccio, D, Marrollo, R, Mauri, C, Mazzariol, A, Morroni, G, Mosca, A, Pagani, GNE, Parisio, EM, Pollini, S, Sarti, M, Sorrentino, A, Trotta, D, Villa, L, Vismara, C & Principe, L 2024, 'Human Campylobacter spp. infections in Italy', European Journal of Clinical Microbiological Infectious Diseases, vol. 43, no. 5, pp. 895-904. https://doi.org/10.1007/s10096-024-04803-0

TY - JOUR

T1 - Human Campylobacter spp. infections in Italy

AU - Zerbato, Verena

AU - Bella, Stefano Di

AU - Pol, Riccardo

AU - Luzzati, Roberto

AU - Sanson, Gianfranco

AU - Ambretti, Simone

AU - Andreoni, Stefano

AU - Aschbacher, Richard

AU - Bernardo, Mariano

AU - Bielli, Alessandra

AU - Brigante, Gioconda

AU - Busetti, Marina

AU - Camarlinghi, Giulio

AU - Carcione, Davide

AU - Carducci, Antonella

AU - Clementi, Nicola

AU - Carretto, Edoardo

AU - Chilleri, Chiara

AU - Codda, Giulia

AU - Consonni, Alessandra

AU - Costantino, Venera

AU - Cortazzo, Venere

AU - Santolo, Manuela Di

AU - Dodaro, Saveria

AU - Fiori, Barbara

AU - García-Fernández, Aurora

AU - Foschi, Claudio

AU - Gobbato, Elisa

AU - Greco, Francesca

AU - Ragione, Roberto Marcello La

AU - Mancini, Nicasio

AU - Maraolo, Alberto Enrico

AU - Marchese, Anna

AU - Marcuccio, Daniela

AU - Marrollo, Roberta

AU - Mauri, Carola

AU - Mazzariol, Annarita

AU - Morroni, Gianluca

AU - Mosca, Adriana

AU - Pagani, Giacomo Nigrisoli . Elisabetta

AU - Parisio, Eva Maria

AU - Pollini, Simona

AU - Sarti, Mario

AU - Sorrentino, Annarita

AU - Trotta, Domenico

AU - Villa, Laura

AU - Vismara, Chiara

AU - Principe, Luigi

PY - 2024

Y1 - 2024

N2 - Purpose\r\n\r\nCampylobacter is a frequent cause of enteric infections with common antimicrobial resistance issues. The most recent reports of campylobacteriosis in Italy include data from 2013 to 2016. We aimed to provide national epidemiological and microbiological data on human Campylobacter infections in Italy during the period 2017–2021.\r\nMethods\r\n\r\nData was collected from 19 Hospitals in 13 Italian Regions. Bacterial identification was performed by mass spectrometry. Antibiograms were determined with Etest or Kirby-Bauer (EUCAST criteria).\r\nResults\r\n\r\nIn total, 5419 isolations of Campylobacter spp. were performed. The most common species were C. jejuni (n = 4535, 83.7%), followed by C. coli (n = 732, 13.5%) and C. fetus (n = 34, 0.6%). The mean age of patients was 34.61 years and 57.1% were males. Outpatients accounted for 54% of the cases detected. Campylobacter were isolated from faeces in 97.3% of cases and in 2.7% from blood. C. fetus was mostly isolated from blood (88.2% of cases). We tested for antimicrobial susceptibility 4627 isolates (85.4%). Resistance to ciprofloxacin and tetracyclines was 75.5% and 54.8%, respectively; resistance to erythromycin was 4.8%; clarithromycin 2% and azithromycin 2%. 50% of C. jejuni and C. coli were resistant to ≥ 2 antibiotics. Over the study period, resistance to ciprofloxacin and tetracyclines significantly decreased (p < 0.005), while resistance to macrolides remained stable.\r\nConclusion\r\n\r\nCampylobacter resistance to fluoroquinolones and tetracyclines in Italy is decreasing but is still high, while macrolides retain good activity.

AB - Purpose\r\n\r\nCampylobacter is a frequent cause of enteric infections with common antimicrobial resistance issues. The most recent reports of campylobacteriosis in Italy include data from 2013 to 2016. We aimed to provide national epidemiological and microbiological data on human Campylobacter infections in Italy during the period 2017–2021.\r\nMethods\r\n\r\nData was collected from 19 Hospitals in 13 Italian Regions. Bacterial identification was performed by mass spectrometry. Antibiograms were determined with Etest or Kirby-Bauer (EUCAST criteria).\r\nResults\r\n\r\nIn total, 5419 isolations of Campylobacter spp. were performed. The most common species were C. jejuni (n = 4535, 83.7%), followed by C. coli (n = 732, 13.5%) and C. fetus (n = 34, 0.6%). The mean age of patients was 34.61 years and 57.1% were males. Outpatients accounted for 54% of the cases detected. Campylobacter were isolated from faeces in 97.3% of cases and in 2.7% from blood. C. fetus was mostly isolated from blood (88.2% of cases). We tested for antimicrobial susceptibility 4627 isolates (85.4%). Resistance to ciprofloxacin and tetracyclines was 75.5% and 54.8%, respectively; resistance to erythromycin was 4.8%; clarithromycin 2% and azithromycin 2%. 50% of C. jejuni and C. coli were resistant to ≥ 2 antibiotics. Over the study period, resistance to ciprofloxacin and tetracyclines significantly decreased (p < 0.005), while resistance to macrolides remained stable.\r\nConclusion\r\n\r\nCampylobacter resistance to fluoroquinolones and tetracyclines in Italy is decreasing but is still high, while macrolides retain good activity.

KW - Campylobacter spp

UR - https://publicatt.unicatt.it/handle/10807/279596

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U2 - 10.1007/s10096-024-04803-0

DO - 10.1007/s10096-024-04803-0

M3 - Article

VL - 43

SP - 895

EP - 904

JO - European Journal of Clinical Microbiological Infectious Diseases

JF - European Journal of Clinical Microbiological Infectious Diseases

IS - 5

ER -

Human Campylobacter spp. infections in Italy

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