Human acellular amniotic membrane implantation for lower third nasal reconstruction: a promising therapy to promote wound healing

Si-Liang Xue, Kai Liu, Ornella Parolini, Yue Wang, Li Deng, Yong-Can Huang

Research output: Contribution to journalArticle


BACKGROUND: The lower third of the nose is one of the most important cosmetic units of the face, and its reconstructive techniques remain a big challenge. As an alternative approach to repair or regenerate the nasal tissue, the biomaterial-based strategy has been extensively investigated. The aim of this study is to determine the safety and efficacy of human acellular amniotic membrane (HAAM) to repair the full-thickness defects in the lower third of the nose in humans. METHODS: In this study, 180 patients who underwent excision of skin lesions of the lower third of the nose from 2012 to 2016 were included; of the patients, 92 received HAAM and Vaseline gauze treatments, and the other 88 patients received Vaseline gauze treatment only. The haemostasis time and the duration of operation were recorded during surgery; after surgery, the time to pain disappearance, scab formation and wound healing, and the wound healing rate were measured. RESULTS: Immediately after the HAAM implantation, a reduction of the haemostasis time and an accelerated disappearance of pain were observed. Compared with the control group, the formation and detachment of scab in patients who received the HAAM implantation were notably accelerated, postoperatively. When the diameter of the lesion exceeded 5 mm, the HAAM implantation was found to enhance the wound healing, although this enhancement was not seen when the diameter was less than 5 mm. Additionally, the HAAM implantation significantly reduced bleeding, wound infection and scar formation, postoperatively. CONCLUSIONS: HAAM-assisted healing is a promising therapy for lower third nasal reconstruction leading to rapid wound healing and fewer complications and thus has considerable potential for extensive clinical application in repairing skin wounds. TRIAL REGISTRATION: ChiCTR1800017618, retrospectively registered on July 08, 2018.
Original languageEnglish
Pages (from-to)34-41
Number of pages8
JournalBurns and Trauma
Publication statusPublished - 2018


  • Acellular amniotic membrane
  • Nasal reconstruction
  • Repair
  • Wound healing


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