HSV-1 and Alzheimer's disease: more than a hypothesis

Roberto Piacentini, Domenica Donatella Li Puma, Cristian Ripoli, Claudio Grassi, Maria Elena Marcocci, Giovanna De Chiara, Maria E. Marcocci, Enrico Garaci, Anna T. Palamara

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)


Among the multiple factors concurring to Alzheimer's disease (AD) pathogenesis, greater attention should be devoted to the role played by infectious agents. Growing epidemiological and experimental evidence suggests that recurrent herpes simplex virus type-1 (HSV-1) infection is a risk factor for AD although the underlying molecular and functional mechanisms have not been fully elucidated yet. Here, we review literature suggesting the involvement of HSV-1 infection in AD also briefly mentioning possible pharmacological implications of these findings.
Original languageEnglish
Pages (from-to)97-97
Number of pages1
JournalFrontiers in Pharmacology
Publication statusPublished - 2014


  • Alzheimer’s disease
  • HSV-1
  • amyloid-β protein
  • recurrent infection
  • γ secretase


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