HSV-1 and Alzheimer's disease: more than a hypothesis

Roberto Piacentini; Giovanna De Chiara; Domenica Donatella Li Puma; Cristian Ripoli; Maria E. Marcocci; Maria Elena Marcocci; Enrico Garaci; Anna T. Palamara; Claudio Grassi

doi:10.3389/fphar.2014.00097

HSV-1 and Alzheimer's disease: more than a hypothesis

Roberto Piacentini, Giovanna De Chiara, Domenica Donatella Li Puma, Cristian Ripoli, Maria E. Marcocci, Maria Elena Marcocci, Enrico Garaci, Anna T. Palamara, Claudio Grassi

Research output: Contribution to journal › Article › peer-review

66 Citations (Scopus)

Abstract

Among the multiple factors concurring to Alzheimer's disease (AD) pathogenesis, greater attention should be devoted to the role played by infectious agents. Growing epidemiological and experimental evidence suggests that recurrent herpes simplex virus type-1 (HSV-1) infection is a risk factor for AD although the underlying molecular and functional mechanisms have not been fully elucidated yet. Here, we review literature suggesting the involvement of HSV-1 infection in AD also briefly mentioning possible pharmacological implications of these findings.

Original language	English
Pages (from-to)	97-97
Number of pages	1
Journal	Frontiers in Pharmacology
Volume	5
DOIs	https://doi.org/10.3389/fphar.2014.00097
Publication status	Published - 2014

Keywords

Alzheimer’s disease
HSV-1
amyloid-β protein
recurrent infection
γ secretase

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10.3389/fphar.2014.00097

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title = "HSV-1 and Alzheimer's disease: more than a hypothesis",

abstract = "Among the multiple factors concurring to Alzheimer's disease (AD) pathogenesis, greater attention should be devoted to the role played by infectious agents. Growing epidemiological and experimental evidence suggests that recurrent herpes simplex virus type-1 (HSV-1) infection is a risk factor for AD although the underlying molecular and functional mechanisms have not been fully elucidated yet. Here, we review literature suggesting the involvement of HSV-1 infection in AD also briefly mentioning possible pharmacological implications of these findings.",

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T1 - HSV-1 and Alzheimer's disease: more than a hypothesis

AU - Piacentini, Roberto

AU - Chiara, Giovanna De

AU - Li Puma, Domenica Donatella

AU - Ripoli, Cristian

AU - Marcocci, Maria E.

AU - Marcocci, Maria Elena

AU - Garaci, Enrico

AU - Palamara, Anna T.

AU - Grassi, Claudio

PY - 2014

Y1 - 2014

N2 - Among the multiple factors concurring to Alzheimer's disease (AD) pathogenesis, greater attention should be devoted to the role played by infectious agents. Growing epidemiological and experimental evidence suggests that recurrent herpes simplex virus type-1 (HSV-1) infection is a risk factor for AD although the underlying molecular and functional mechanisms have not been fully elucidated yet. Here, we review literature suggesting the involvement of HSV-1 infection in AD also briefly mentioning possible pharmacological implications of these findings.

AB - Among the multiple factors concurring to Alzheimer's disease (AD) pathogenesis, greater attention should be devoted to the role played by infectious agents. Growing epidemiological and experimental evidence suggests that recurrent herpes simplex virus type-1 (HSV-1) infection is a risk factor for AD although the underlying molecular and functional mechanisms have not been fully elucidated yet. Here, we review literature suggesting the involvement of HSV-1 infection in AD also briefly mentioning possible pharmacological implications of these findings.

KW - Alzheimer’s disease

KW - HSV-1

KW - amyloid-β protein

KW - recurrent infection

KW - γ secretase

KW - Alzheimer’s disease

KW - HSV-1

KW - amyloid-β protein

KW - recurrent infection

KW - γ secretase

UR - http://hdl.handle.net/10807/59536

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DO - 10.3389/fphar.2014.00097

M3 - Article

SN - 1663-9812

VL - 5

SP - 97

EP - 97

JO - Frontiers in Pharmacology

JF - Frontiers in Pharmacology

ER -

HSV-1 and Alzheimer's disease: more than a hypothesis

Abstract

Keywords

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