Abstract
Banks of genetically characterized cancer stem cells (CSCs) isolated from individual patients and grown as spheroids offer an invaluable approach to identify genetic determinants of drug resistance versus sensitivity, and to study new stem cell-directed therapies. Here, we describe our standardized procedure for in vitro drug screening on colorectal CSCs, taking irinotecan as an example.
| Original language | English |
|---|---|
| Title of host publication | Cancer Stem Cells: Methods and Protocols, Methods in Molecular Biology, |
| Publisher | HUMANA PRESS INC |
| Pages | 107-115 |
| Number of pages | 9 |
| Volume | 1692 |
| ISBN (Print) | 9781493974009 |
| DOIs | |
| Publication status | Published - 2018 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Genetics
Keywords
- CSC
- Cancer stem cell culture
- Colorectal cancer
- Drug resistance
- Drug screening
- Genetics
- In vitro assays
- Molecular Biology
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