How to Assess Drug Resistance in Cancer Stem Cells

Maria Laura De Angelis; Ruggero De Maria Marchiano; Marta Baiocchi

doi:10.1007/978-1-4939-7401-6_10

How to Assess Drug Resistance in Cancer Stem Cells

Maria Laura De Angelis
, Ruggero De Maria Marchiano
, Marta Baiocchi

Istituto Superiore di Sanita

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Citations (Scopus)

Abstract

Banks of genetically characterized cancer stem cells (CSCs) isolated from individual patients and grown as spheroids offer an invaluable approach to identify genetic determinants of drug resistance versus sensitivity, and to study new stem cell-directed therapies. Here, we describe our standardized procedure for in vitro drug screening on colorectal CSCs, taking irinotecan as an example.

Original language	English
Title of host publication	Cancer Stem Cells: Methods and Protocols
Pages	N/A
Number of pages	9
DOIs	https://doi.org/10.1007/978-1-4939-7401-6_10
Publication status	Published - 2017

Publication series

Name	METHODS IN MOLECULAR BIOLOGY

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cancer stem cells
drug screening

Access to Document

10.1007/978-1-4939-7401-6_10

Cite this

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title = "How to Assess Drug Resistance in Cancer Stem Cells",

abstract = "Banks of genetically characterized cancer stem cells (CSCs) isolated from individual patients and grown as spheroids offer an invaluable approach to identify genetic determinants of drug resistance versus sensitivity, and to study new stem cell-directed therapies. Here, we describe our standardized procedure for in vitro drug screening on colorectal CSCs, taking irinotecan as an example.",

keywords = "cancer stem cells, drug screening, cancer stem cells, drug screening",

author = "\{De Angelis\}, \{Maria Laura\} and \{De Maria Marchiano\}, Ruggero and Marta Baiocchi",

year = "2017",

doi = "10.1007/978-1-4939-7401-6\_10",

language = "English",

isbn = "1588299384",

series = "METHODS IN MOLECULAR BIOLOGY",

pages = "N/A",

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TY - CHAP

T1 - How to Assess Drug Resistance in Cancer Stem Cells

AU - De Angelis, Maria Laura

AU - De Maria Marchiano, Ruggero

AU - Baiocchi, Marta

PY - 2017

Y1 - 2017

N2 - Banks of genetically characterized cancer stem cells (CSCs) isolated from individual patients and grown as spheroids offer an invaluable approach to identify genetic determinants of drug resistance versus sensitivity, and to study new stem cell-directed therapies. Here, we describe our standardized procedure for in vitro drug screening on colorectal CSCs, taking irinotecan as an example.

AB - Banks of genetically characterized cancer stem cells (CSCs) isolated from individual patients and grown as spheroids offer an invaluable approach to identify genetic determinants of drug resistance versus sensitivity, and to study new stem cell-directed therapies. Here, we describe our standardized procedure for in vitro drug screening on colorectal CSCs, taking irinotecan as an example.

KW - cancer stem cells

KW - drug screening

KW - cancer stem cells

KW - drug screening

UR - http://hdl.handle.net/10807/111255

U2 - 10.1007/978-1-4939-7401-6_10

DO - 10.1007/978-1-4939-7401-6_10

M3 - Chapter

SN - 1588299384

T3 - METHODS IN MOLECULAR BIOLOGY

SP - N/A

BT - Cancer Stem Cells: Methods and Protocols

ER -

How to Assess Drug Resistance in Cancer Stem Cells

Abstract

Publication series

UN SDGs

Keywords

Access to Document

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