How to Assess Drug Resistance in Cancer Stem Cells

Ruggero De Maria Marchiano, Maria Laura De Angelis, Marta Baiocchi

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

Banks of genetically characterized cancer stem cells (CSCs) isolated from individual patients and grown as spheroids offer an invaluable approach to identify genetic determinants of drug resistance versus sensitivity, and to study new stem cell-directed therapies. Here, we describe our standardized procedure for in vitro drug screening on colorectal CSCs, taking irinotecan as an example.
Original languageEnglish
Title of host publicationCancer Stem Cells: Methods and Protocols
PagesN/A
Number of pages9
DOIs
Publication statusPublished - 2017

Publication series

NameMETHODS IN MOLECULAR BIOLOGY

Keywords

  • cancer stem cells
  • drug screening

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