How Should We Measure the Quality of Lymphadenectomy for Gastric Cancer? Anatomical Versus Numerical Criterion

Fausto Rosa, Alberto Biondi, Sergio Alfieri, Roberto Persiani, Domenico D'Ugo, Stefano Rausei, Federica Galli, Georgios Lianos, Andrea Cossu, Francesco Martignoni, Ferdinando Carlo Maria Cananzi, Uberto Fumagalli, Vittorio Quagliuolo, Riccardo Rosati

Research output: Contribution to journalArticle

Abstract

Aim: To compare anatomical with numerical criterion to measure the quality of lymphadenectomy for gastric cancer. Patients and Methods: We analyzed 447 gastric cancer patients with resectable tumor stage (R0 resection) with at least 16 examined lymph nodes. Results: Of 447 patients, 82.6% underwent D2 lymphadenectomy for a median of total examined lymph nodes of 28. The 7-year disease-specific survival rate for the whole sample was 71.4%. Survival was significantly different between patients treated with D2 and D1 lymphadenectomy (77.4% versus 44.3%; p < 0.001) and between patients with total examined lymph nodes ≥ 28 and < 28 (74.5% versus 62.3%; p = 0.041). Anatomical criterion significantly differentiated 7-year survival in patients stratified according to a numerical parameter. Conclusion: We should still consider the anatomical criterion as the best item to measure the quality of lymphadenectomy for gastric cancer.
Original languageEnglish
Pages (from-to)N/A-N/A
JournalJournal of Gastrointestinal Cancer
DOIs
Publication statusPublished - 2019

Keywords

  • Cancer-related survival
  • Locally advanced gastric cancer
  • Lymphadenectomy
  • Number of removed lymph nodes

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