Hormones and antioxidant systems: role of pituitary and pituitary-dependent axes.

Antonio Mancini, Andrea Silvestrini, Elisabetta Meucci, Alfredo Pontecorvi, Vincenzo Di Donna, Erika Leone, Roberto Festa, Gian Paolo Littarru

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Oxidative stress, a condition defined as unbalancing between production of free radicals and antioxidant defenses, is an important pathogenetic mechanism in different diseases. Despite the abundant literature, many aspects of hormone role in regulating antioxidant synthesis and activity still remain obscure. Therefore, we reviewed experimental data, in vivo and in vitro, about the effects of the different pituitary- dependent axes on antioxidant levels, trying to give a broad view from hormones which also have antioxidant properties to the classic antioxidants, from the lipophilic antioxidant Coenzyme Q10, strictly related to thyroid function, to total antioxidant capacity, a measure of non-protein non-enzymatic antioxidants in serum and other biological fluids. Taken together, these data underline the importance of oxidative stress in various pituitary-dependent disorders, suggesting a possible clinical usefulness of antioxidant molecules.
Original languageEnglish
Pages (from-to)422-433
Number of pages12
JournalJournal of Endocrinological Investigation
Volume2010
Publication statusPublished - 2010

Keywords

  • antioxidants
  • pituitary
  • thyroid

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