Highly bactericidal Ag nanoparticle films obtained by cluster beam deposition

Emanuele Cavaliere, Sebastiano De Cesari, Giulia Landini, Eleonora Riccobono, Lucia Pallecchi, Gian Maria Rossolini, Luca Gavioli

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


The recent emergence of bacterial pathogens resistant to most or all available antibiotics is among the major global public health problems. As indirect transmission through contaminated surfaces is a main route of dissemination for most of such pathogens, the implementation of effective antimicrobial surfaces has been advocated as a promising approach for their containment, especially in the hospital settings. However, traditional wet synthesis methods of nanoparticle-based antimicrobial materials leave a number of key points open for metal surfaces: such as adhesion to the surface and nanoparticle coalescence. Here we demonstrate an alternative route, i.e. supersonic cluster beam deposition, to obtain antimicrobial Ag nanoparticle films deposited directly on surfaces. The synthesized films are simple to produce with controlled density and thickness, are stable over time, and are shown to be highly bactericidal against major Gram positive and Gram negative bacterial pathogens, including extensively drug-resistant strains.
Original languageEnglish
Pages (from-to)1417-1423
Number of pages7
Publication statusPublished - 2015


  • Ag nanoparticle-based antimicrobial films
  • Atomic force microscopy
  • Bactericidal activity
  • Electron spectroscopies
  • Extensively drug-resistant bacteria
  • Supersonic cluster beam deposition


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