Higher risk of tuberculosis reactivation when anti-TNF is combined with immunosuppressive agents: a systematic review of randomized controlled trials

Alessandro Armuzzi, Roberto Lorenzetti, Angelo Zullo, Lorenzo Ridola, Andrea Picchianti Diamanti, Bruno Laganà, Luigi Gatta, Alberto Migliore, Cesare Hassan, Vincenzo Bruzzese

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Treatment with tumour necrosis factor antagonists (anti-TNF) has been recognized as a risk factor for tuberculosis (TB) reactivation. Our aim was to evaluate risk of TB reactivation in rheumatologic and non-rheumatologic diseases treated with the same anti-TNF agents with and without concomitant therapies.
Original languageEnglish
Pages (from-to)547-554
Number of pages8
JournalAnnals of Medicine
Volume46
DOIs
Publication statusPublished - 2014

Keywords

  • Ankylosing spondylitis
  • anti-TNF
  • inflammatory bowel diseases
  • methotrexate
  • psoriasis
  • rheumatoid arthritis
  • tuberculosis

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