High prevalence of hepatitis B virus infection in B-cell non-Hodgkin's lymphoma.

Livio Pagano, Fabrizio Marcucci, Alfonso Mele, Enea Spada, Angela Candido, Elvira Bianco, Alessandro Pulsoni, Paola Chionne, Elisabetta Madonna, Rodolfo Cotichini, Anna Barbui, Amalia De Renzo, Fausto Dore, Emilio Iannitto, Vincenzo Liso, Bruno Martino, Marco Montanaro, Pellegrino Musto, Maria Rapicetta

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120 Citations (Scopus)


In this hospital-based, multicenter case-control study we investigated the prevalence of hepatitis B virus (HBV)-related markers and HBV/hepatitis C virus (HCV) co-infection among B-cell non-Hodgkin’s lymphoma (B-NHL) cases and controls. Four hundred newly diagnosed B-NHL cases and 392 controls from other departments of the same hospitals were studied. The prevalence of positivity for hepatitis B surface antigen (HBsAg) was 8.5% among B-NHL cases and 2.8% among controls (adjusted odds ratio, 3.67; 95% confidence interval, 1.75-7.66). HBV/HCV co-infection was found in four cases, but in no controls. The finding of a positive association between HBV infection and BNHL raises the possibility that HBV may play an etiologic role in the induction of B-NHL.
Original languageEnglish
Pages (from-to)554-557
Number of pages4
Publication statusPublished - 2006


  • hepatitis B
  • lymphoma


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