High-mobility group box-1 protein promotes angiogenesis after peripheral ischemia in diabetic mice through a VEGF-dependent mechanism

Federico Biscetti; Giuseppe Straface; Raimondo De Cristofaro; S Lancellotti; P Rizzo; Vincenzo Arena; E Stigliano; Giovanni Pecorini; K Egashira; Giulia De Angelis; G Ghirlanda; Andrea Flex

doi:10.2337/db09-1507

High-mobility group box-1 protein promotes angiogenesis after peripheral ischemia in diabetic mice through a VEGF-dependent mechanism

Federico Biscetti^*
, Giuseppe Straface
, Raimondo De Cristofaro
, S Lancellotti
, P Rizzo
, Vincenzo Arena
, E Stigliano
, Giovanni Pecorini
, K Egashira
, Giulia De Angelis
, G Ghirlanda
, Andrea Flex

^*Corresponding author

University of Rome La Sapienza

Research output: Contribution to journal › Article › peer-review

84 Citations (SciVal)

Abstract

High-mobility group box-1 (HMGB1) protein is a nuclear DNA-binding protein released from necrotic cells, inducing inflammatory responses and promoting tissue repair and angiogenesis. Diabetic human and mouse tissues contain lower levels of HMGB1 than their normoglycemic counterparts. Deficient angiogenesis after ischemia contributes to worse outcomes of peripheral arterial disease in patients with diabetes. To test the hypothesis that HMGB1 enhances ischemia-induced angiogenesis in diabetes, we administered HMGB1 protein in a mouse hind limb ischemia model using diabetic mice.

Original language	English
Pages (from-to)	1496-1505
Number of pages	10
Journal	Diabetes
Volume	59
Issue number	6
DOIs	https://doi.org/10.2337/db09-1507
Publication status	Published - 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Internal Medicine
Endocrinology, Diabetes and Metabolism

Keywords

Animals
Blood Flow Velocity
Diabetes Mellitus
Experimental
HMGB1 Protein
Hindlimb
Humans
Inbred C57BL
Ischemia
Male
Mice
Muscle
Neovascularization
Pathologic
Physiologic
Skeletal
Vascular Endothelial Growth Factor A

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10.2337/db09-1507

Cite this

Biscetti, F., Straface, G., De Cristofaro, R., Lancellotti, S., Rizzo, P., Arena, V., Stigliano, E., Pecorini, G., Egashira, K., De Angelis, G., Ghirlanda, G., & Flex, A. (2010). High-mobility group box-1 protein promotes angiogenesis after peripheral ischemia in diabetic mice through a VEGF-dependent mechanism. Diabetes, 59(6), 1496-1505. https://doi.org/10.2337/db09-1507

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author = "Federico Biscetti and Giuseppe Straface and \{De Cristofaro\}, Raimondo and S Lancellotti and P Rizzo and Vincenzo Arena and E Stigliano and Giovanni Pecorini and K Egashira and \{De Angelis\}, Giulia and G Ghirlanda and Andrea Flex",

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Biscetti, F, Straface, G, De Cristofaro, R, Lancellotti, S, Rizzo, P, Arena, V, Stigliano, E, Pecorini, G, Egashira, K, De Angelis, G, Ghirlanda, G & Flex, A 2010, 'High-mobility group box-1 protein promotes angiogenesis after peripheral ischemia in diabetic mice through a VEGF-dependent mechanism', Diabetes, vol. 59, no. 6, pp. 1496-1505. https://doi.org/10.2337/db09-1507

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AU - Biscetti, Federico

AU - Straface, Giuseppe

AU - De Cristofaro, Raimondo

AU - Lancellotti, S

AU - Rizzo, P

AU - Arena, Vincenzo

AU - Stigliano, E

AU - Pecorini, Giovanni

AU - Egashira, K

AU - De Angelis, Giulia

AU - Ghirlanda, G

AU - Flex, Andrea

PY - 2010

Y1 - 2010

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High-mobility group box-1 protein promotes angiogenesis after peripheral ischemia in diabetic mice through a VEGF-dependent mechanism

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

Keywords

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