High-mobility group box-1 protein promotes angiogenesis after peripheral ischemia in diabetic mice through a VEGF-dependent mechanism

Federico Biscetti; Giuseppe Straface; Raimondo De Cristofaro; Stefano Lancellotti; Paola Rizzo; Vincenzo Arena; Egidio Stigliano; Giovanni Pecorini; Kensuke Egashira; Giulia De Angelis; Giovanni Ghirlanda; Andrea Flex

doi:10.2337/db09-1507

High-mobility group box-1 protein promotes angiogenesis after peripheral ischemia in diabetic mice through a VEGF-dependent mechanism

Federico Biscetti, Giuseppe Straface, Raimondo De Cristofaro, Stefano Lancellotti, Paola Rizzo, Vincenzo Arena, Egidio Stigliano, Giovanni Pecorini, Kensuke Egashira, Giulia De Angelis, Giovanni Ghirlanda, Andrea Flex

Kyushu University

Research output: Contribution to journal › Article › peer-review

84 Citations (SciVal)

Abstract

High-mobility group box-1 (HMGB1) protein is a nuclear DNA-binding protein released from necrotic cells, inducing inflammatory responses and promoting tissue repair and angiogenesis. Diabetic human and mouse tissues contain lower levels of HMGB1 than their normoglycemic counterparts. Deficient angiogenesis after ischemia contributes to worse outcomes of peripheral arterial disease in patients with diabetes. To test the hypothesis that HMGB1 enhances ischemia-induced angiogenesis in diabetes, we administered HMGB1 protein in a mouse hind limb ischemia model using diabetic mice.

Original language	English
Pages (from-to)	1496-1505
Number of pages	10
Journal	Diabetes
Volume	59
DOIs	https://doi.org/10.2337/db09-1507
Publication status	Published - 2010

Keywords

Animals
Blood Flow Velocity
Diabetes Mellitus, Experimental
HMGB1 Protein
Hindlimb
Humans
Ischemia
Male
Mice
Mice, Inbred C57BL
Muscle, Skeletal
Neovascularization, Pathologic
Neovascularization, Physiologic
Vascular Endothelial Growth Factor A

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2337/db09-1507

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Biscetti, F., Straface, G., De Cristofaro, R., Lancellotti, S., Rizzo, P., Arena, V., Stigliano, E., Pecorini, G., Egashira, K., De Angelis, G., Ghirlanda, G., & Flex, A. (2010). High-mobility group box-1 protein promotes angiogenesis after peripheral ischemia in diabetic mice through a VEGF-dependent mechanism. Diabetes, 59, 1496-1505. https://doi.org/10.2337/db09-1507

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author = "Federico Biscetti and Giuseppe Straface and {De Cristofaro}, Raimondo and Stefano Lancellotti and Paola Rizzo and Vincenzo Arena and Egidio Stigliano and Giovanni Pecorini and Kensuke Egashira and {De Angelis}, Giulia and Giovanni Ghirlanda and Andrea Flex",

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doi = "10.2337/db09-1507",

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publisher = "American Diabetes Association:National Service Center, 1701 North Beaureguard Street:Alexandria, VA 22311:(800)232-3472, (703)549-1500, INTERNET: http://www.diabetes.org/diabetscare, Fax: (703)549-6995",

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T1 - High-mobility group box-1 protein promotes angiogenesis after peripheral ischemia in diabetic mice through a VEGF-dependent mechanism

AU - Biscetti, Federico

AU - Straface, Giuseppe

AU - De Cristofaro, Raimondo

AU - Lancellotti, Stefano

AU - Rizzo, Paola

AU - Arena, Vincenzo

AU - Stigliano, Egidio

AU - Pecorini, Giovanni

AU - Egashira, Kensuke

AU - De Angelis, Giulia

AU - Ghirlanda, Giovanni

AU - Flex, Andrea

PY - 2010

Y1 - 2010

N2 - High-mobility group box-1 (HMGB1) protein is a nuclear DNA-binding protein released from necrotic cells, inducing inflammatory responses and promoting tissue repair and angiogenesis. Diabetic human and mouse tissues contain lower levels of HMGB1 than their normoglycemic counterparts. Deficient angiogenesis after ischemia contributes to worse outcomes of peripheral arterial disease in patients with diabetes. To test the hypothesis that HMGB1 enhances ischemia-induced angiogenesis in diabetes, we administered HMGB1 protein in a mouse hind limb ischemia model using diabetic mice.

AB - High-mobility group box-1 (HMGB1) protein is a nuclear DNA-binding protein released from necrotic cells, inducing inflammatory responses and promoting tissue repair and angiogenesis. Diabetic human and mouse tissues contain lower levels of HMGB1 than their normoglycemic counterparts. Deficient angiogenesis after ischemia contributes to worse outcomes of peripheral arterial disease in patients with diabetes. To test the hypothesis that HMGB1 enhances ischemia-induced angiogenesis in diabetes, we administered HMGB1 protein in a mouse hind limb ischemia model using diabetic mice.

KW - Animals

KW - Blood Flow Velocity

KW - Diabetes Mellitus, Experimental

KW - HMGB1 Protein

KW - Hindlimb

KW - Humans

KW - Ischemia

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

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KW - Neovascularization, Pathologic

KW - Neovascularization, Physiologic

KW - Vascular Endothelial Growth Factor A

KW - Animals

KW - Blood Flow Velocity

KW - Diabetes Mellitus, Experimental

KW - HMGB1 Protein

KW - Hindlimb

KW - Humans

KW - Ischemia

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Muscle, Skeletal

KW - Neovascularization, Pathologic

KW - Neovascularization, Physiologic

KW - Vascular Endothelial Growth Factor A

UR - http://hdl.handle.net/10807/32841

U2 - 10.2337/db09-1507

DO - 10.2337/db09-1507

M3 - Article

SN - 0012-1797

VL - 59

SP - 1496

EP - 1505

JO - Diabetes

JF - Diabetes

ER -

High-mobility group box-1 protein promotes angiogenesis after peripheral ischemia in diabetic mice through a VEGF-dependent mechanism

Abstract

Keywords

UN SDGs

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