High frequency oscillations after median nerve stimulations in healthy children and adolescents

Domenico Restuccia, Sergio Zanini, Ivana Del Piero, Lucia Martucci

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The aim of the present research was to address somatosensory high frequency oscillations (400–800 Hz) in healthy children and adolescents in comparison with healthy adults. We recorded somatosensory evoked potentials following median nerve stimulation in nineteen resting healthy children/adolescents and in nineteen resting healthy adults with eyes closed. We administered six consecutive stimulation blocks (500 sweeps each). The presynaptic component of high frequency oscillations amplitudes was smaller in healthy children/adolescents than in healthy adults (no difference between groups was found as far as the postsynaptic component was concerned). Healthy children/adolescents had smaller presynaptic component than the postsynaptic one (the postsynaptic component amplitude was 145% of the presynaptic one), while healthy adults showed the opposite (reduction of the postsynaptic component to 80% of the presynaptic one). No habituation phenomena concerning high frequency oscillation amplitudes were registered in neither healthy children/adolescents nor healthy adults. These findings suggest that healthy children/adolescents present with significantly different pattern of somatosensory high frequency oscillations compared with healthy adults’ ones. This different pattern is reasonably expression of higher cortical excitability of the developing brain cortex.
Original languageEnglish
Pages (from-to)68-72
Number of pages5
JournalInternational Journal of Developmental Neuroscience
Volume61
DOIs
Publication statusPublished - 2017

Keywords

  • Adolescent
  • Analysis of Variance
  • Area Under Curve
  • Biophysics
  • Child
  • Children/adolescent
  • Cortical excitability
  • Developing brain
  • Electric Stimulation
  • Evoked Potentials, Somatosensory
  • Female
  • High frequency oscillations
  • Humans
  • Male
  • Median Nerve
  • Somatosensory Cortex
  • Somatosensory evoked potentials

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