High dose tigecycline in critically ill patients with severe infections due to multidrug-resistant bacteria

Gennaro De Pascale; Luca Montini; Mariano Alberto Pennisi; Valentina Bernini; Riccardo Maviglia; Giuseppe Bello; Teresa Spanu; Mario Tumbarello; Massimo Antonelli

doi:10.1186/cc13858

High dose tigecycline in critically ill patients with severe infections due to multidrug-resistant bacteria

Gennaro De Pascale
, Luca Montini
, Mariano Alberto Pennisi
, Valentina Bernini
, Riccardo Maviglia
, Giuseppe Bello
, Teresa Spanu
, Mario Tumbarello
, Massimo Antonelli

Research output: Contribution to journal › Article

135 Citations (Scopus)

Abstract

The high incidence of multidrug-resistant (MDR) bacteria among patients admitted to ICUs has determined an increase of tigecycline (TGC) use for the treatment of severe infections. Many concerns have been raised about the efficacy of this molecule and increased dosages have been proposed. Our purpose is to investigate TGC safety and efficacy at higher than standard doses.

Original language	English
Pages (from-to)	R90-R90
Number of pages	9
Journal	Critical Care
Volume	18
Issue number	3
DOIs	https://doi.org/10.1186/cc13858
Publication status	Published - 2014

All Science Journal Classification (ASJC) codes

Critical Care and Intensive Care Medicine

Keywords

tygecicline

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10.1186/cc13858

Cite this

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abstract = "The high incidence of multidrug-resistant (MDR) bacteria among patients admitted to ICUs has determined an increase of tigecycline (TGC) use for the treatment of severe infections. Many concerns have been raised about the efficacy of this molecule and increased dosages have been proposed. Our purpose is to investigate TGC safety and efficacy at higher than standard doses.",

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AU - De Pascale, Gennaro

AU - Montini, Luca

AU - Pennisi, Mariano Alberto

AU - Bernini, Valentina

AU - Maviglia, Riccardo

AU - Bello, Giuseppe

AU - Spanu, Teresa

AU - Tumbarello, Mario

AU - Antonelli, Massimo

PY - 2014

Y1 - 2014

N2 - The high incidence of multidrug-resistant (MDR) bacteria among patients admitted to ICUs has determined an increase of tigecycline (TGC) use for the treatment of severe infections. Many concerns have been raised about the efficacy of this molecule and increased dosages have been proposed. Our purpose is to investigate TGC safety and efficacy at higher than standard doses.

AB - The high incidence of multidrug-resistant (MDR) bacteria among patients admitted to ICUs has determined an increase of tigecycline (TGC) use for the treatment of severe infections. Many concerns have been raised about the efficacy of this molecule and increased dosages have been proposed. Our purpose is to investigate TGC safety and efficacy at higher than standard doses.

KW - tygecicline

UR - https://publicatt.unicatt.it/handle/10807/65015

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JO - Critical Care

JF - Critical Care

IS - 3

ER -

High dose tigecycline in critically ill patients with severe infections due to multidrug-resistant bacteria

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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