High dose tigecycline in critically ill patients with severe infections due to multidrug-resistant bacteria

Gennaro De Pascale; Luca Montini; Mariano Alberto Pennisi; Valentina Bernini; Riccardo Maviglia; Giuseppe Bello; Teresa Spanu; Mario Tumbarello; Massimo Antonelli

doi:10.1186/cc13858

High dose tigecycline in critically ill patients with severe infections due to multidrug-resistant bacteria

Gennaro De Pascale, Luca Montini, Mariano Alberto Pennisi, Valentina Bernini, Riccardo Maviglia, Giuseppe Bello, Teresa Spanu, Mario Tumbarello, Massimo Antonelli

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Abstract

The high incidence of multidrug-resistant (MDR) bacteria among patients admitted to ICUs has determined an increase of tigecycline (TGC) use for the treatment of severe infections. Many concerns have been raised about the efficacy of this molecule and increased dosages have been proposed. Our purpose is to investigate TGC safety and efficacy at higher than standard doses.

Original language	English
Pages (from-to)	R90-R90
Number of pages	9
Journal	Critical Care
Volume	18
DOIs	https://doi.org/10.1186/cc13858
Publication status	Published - 2014

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tygecicline

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10.1186/cc13858

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title = "High dose tigecycline in critically ill patients with severe infections due to multidrug-resistant bacteria",

abstract = "The high incidence of multidrug-resistant (MDR) bacteria among patients admitted to ICUs has determined an increase of tigecycline (TGC) use for the treatment of severe infections. Many concerns have been raised about the efficacy of this molecule and increased dosages have been proposed. Our purpose is to investigate TGC safety and efficacy at higher than standard doses.",

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T1 - High dose tigecycline in critically ill patients with severe infections due to multidrug-resistant bacteria

AU - De Pascale, Gennaro

AU - Montini, Luca

AU - Pennisi, Mariano Alberto

AU - Bernini, Valentina

AU - Maviglia, Riccardo

AU - Bello, Giuseppe

AU - Spanu, Teresa

AU - Tumbarello, Mario

AU - Antonelli, Massimo

PY - 2014

Y1 - 2014

N2 - The high incidence of multidrug-resistant (MDR) bacteria among patients admitted to ICUs has determined an increase of tigecycline (TGC) use for the treatment of severe infections. Many concerns have been raised about the efficacy of this molecule and increased dosages have been proposed. Our purpose is to investigate TGC safety and efficacy at higher than standard doses.

AB - The high incidence of multidrug-resistant (MDR) bacteria among patients admitted to ICUs has determined an increase of tigecycline (TGC) use for the treatment of severe infections. Many concerns have been raised about the efficacy of this molecule and increased dosages have been proposed. Our purpose is to investigate TGC safety and efficacy at higher than standard doses.

KW - tygecicline

UR - http://hdl.handle.net/10807/65015

U2 - 10.1186/cc13858

DO - 10.1186/cc13858

M3 - Article

SN - 1364-8535

VL - 18

SP - R90-R90

JO - Critical Care

JF - Critical Care

ER -

High dose tigecycline in critically ill patients with severe infections due to multidrug-resistant bacteria

Abstract

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