Health-related quality of life in chronic myeloid leukemia patients receiving long-term therapy with imatinib compared with the general population

Fabio Efficace, Michele Baccarani, Massimo Breccia, Giuliana Alimena, Gianantonio Rosti, Francesco Cottone, Giorgio Lambertenghi Deliliers, Claudia Baratè, Antonella Russo Rossi, Giuseppe Fioritoni, Luigia Luciano, Diamante Turri, Bruno Martino, Francesco Di Raimondo, Melissa Dabusti, Micaela Bergamaschi, Pietro Leoni, Maria Pina Simula, Luciano Levato, Stefano UliscianiDino Veneri, Simona Sica, Alessandro Rambaldi, Marco Vignetti, Franco Mandelli

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157 Citations (Scopus)


The main objective of this study was to investigate whether patients with chronic myeloid leukemia (CML) in treatment with long-term therapy imatinib have a different health-related quality-of-life (HRQOL) profile compared with the general population. In total, 448 CML patients were enrolled, and the SF-36 Health Survey was used to compare generic HRQOL profiles. Symptoms were also assessed. HRQOL comparisons were adjusted for key possible confounders. The median age of patients was 57 years and the median time of imatinib treatment was 5 years (range 3-9 years). The largest HRQOL differences were found in younger patients. In particular, patients aged between 18 and 39 years had marked impairments in role limitations because of physical and emotional problems, respectively: -22.6 (P < .001), -22.3 (P < .001). Patients with CML age 60 or older had a HRQOL profile very similar to that reported by the general population. Women had a worse profile than men when each were compared with their peers in the general population. Fatigue was the most frequently reported symptom. The HRQOL of CML patients is comparable with that of population norms in many areas, however, younger and female patients seem to report the major limitations.
Original languageEnglish
Pages (from-to)4554-4560
Number of pages7
Publication statusPublished - 2011


  • Adolescent
  • Adult
  • Antineoplastic Agents
  • Cross-Sectional Studies
  • Female
  • Health Status
  • Humans
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Maintenance Chemotherapy
  • Male
  • Middle Aged
  • Piperazines
  • Population
  • Pyrimidines
  • Quality of Life
  • Time Factors
  • Young Adult


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