Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells.

Maria Cristina Mele, Paola Palozza, Alma Boninsegna Lucarelli, Rossella Emanuela Simone, Assunta Catalano, Torelli Cristiana, Picci Nevio

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118 Citations (Scopus)

Abstract

The growth-inhibitory effects of the astaxanthin-rich Haematococcus pluvialis were studied in HCT-116 colon cancer cells. H. pluvialis extract (5 25 μg/ml) inhibited cell growth in a dose- and time-dependent manner, by arresting cell cycle progression and by promoting apoptosis. At 25 μg/ml of H. pluvialis extract, an increase of p53, p21WAF-1/CIP-1 and p27 expression (220%, 160%, 250%, respectively) was observed, concomitantly with a decrease of cyclin D1 expression (58%) and AKT phosphorylation (21%). Moreover, the extract, at the same concentration, strongly up-regulated apoptosis by modifying the ratio of Bax/Bcl-2 and Bcl-XL, and increased the phosphorylation of p38, JNK, and ERK1/2 by 160%, 242%, 280%, respectively. Growth-inhibitory effects by H. pluvialis were also observed in HT-29, LS-174, WiDr, SW-480 cells. This study suggests that H. pluvialis may protect from colon cancer.
Original languageEnglish
Pages (from-to)108-117
Number of pages10
JournalCancer Letters
Volume28
Publication statusPublished - 2009

Keywords

  • apoptosis
  • astaxanthin
  • cell cycle
  • cell survivor
  • haematococcus pluvialis
  • human colon cancer cell

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