Graft rejection after femtosecond laser-assisted deep anterior lamellar keratoplasty: report of 3 cases.

Luigi Mosca; Romina Fasciani; Luca Mosca; Laura Guccione; Ef Legrottaglie; Andrea Siniscalco; Monica Riso; Emilio Balestrazzi

Graft rejection after femtosecond laser-assisted deep anterior lamellar keratoplasty: report of 3 cases.

Luigi Mosca, Romina Fasciani, Luca Mosca, Laura Guccione, Ef Legrottaglie, Andrea Siniscalco, Monica Riso, Emilio Balestrazzi

Research output: Contribution to journal › Article

8 Citations (Scopus)

Abstract

PURPOSE: To report 3 cases of stromal rejection after deep anterior lamellar keratoplasty (DALK) assisted by a femtosecond laser. METHODS: Three keratoconus eyes of 2 men (22 and 30 years old) and 1 woman (24 years old) who had DALK with a 60-kHz femtosecond laser developed intrastromal graft rejection with superficial and deep neovascularization after 6, 15, and 12 months, respectively. All patients underwent confocal microscopy and were treated with topical steroid therapy. RESULTS: In vivo confocal microscopy revealed cellular inflammatory infiltrates in the subepithelial and middle stroma of the donor lamella without involvement of the endothelium. Graft rejection was rapidly reversed with topical steroid therapy, and a clear cornea was restored in all cases. CONCLUSIONS: Graft rejection remains a significant complication of lamellar surgery but is associated with good tissue restoration and complete visual recovery.

Original language	English
Pages (from-to)	912-916
Number of pages	5
Journal	Cornea
Publication status	Published - 2011
Externally published	Yes

Keywords

femtosecond laser
graft rejection
lamellar keratoplasty

Cite this

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title = "Graft rejection after femtosecond laser-assisted deep anterior lamellar keratoplasty: report of 3 cases.",

abstract = "PURPOSE: To report 3 cases of stromal rejection after deep anterior lamellar keratoplasty (DALK) assisted by a femtosecond laser. METHODS: Three keratoconus eyes of 2 men (22 and 30 years old) and 1 woman (24 years old) who had DALK with a 60-kHz femtosecond laser developed intrastromal graft rejection with superficial and deep neovascularization after 6, 15, and 12 months, respectively. All patients underwent confocal microscopy and were treated with topical steroid therapy. RESULTS: In vivo confocal microscopy revealed cellular inflammatory infiltrates in the subepithelial and middle stroma of the donor lamella without involvement of the endothelium. Graft rejection was rapidly reversed with topical steroid therapy, and a clear cornea was restored in all cases. CONCLUSIONS: Graft rejection remains a significant complication of lamellar surgery but is associated with good tissue restoration and complete visual recovery.",

keywords = "femtosecond laser, graft rejection, lamellar keratoplasty, femtosecond laser, graft rejection, lamellar keratoplasty",

author = "Luigi Mosca and Romina Fasciani and Luca Mosca and Laura Guccione and Ef Legrottaglie and Andrea Siniscalco and Monica Riso and Emilio Balestrazzi",

year = "2011",

language = "English",

pages = "912--916",

journal = "Cornea",

issn = "0277-3740",

publisher = "Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320",

}

TY - JOUR

T1 - Graft rejection after femtosecond laser-assisted deep anterior lamellar keratoplasty: report of 3 cases.

AU - Mosca, Luigi

AU - Fasciani, Romina

AU - Mosca, Luca

AU - Guccione, Laura

AU - Legrottaglie, Ef

AU - Siniscalco, Andrea

AU - Riso, Monica

AU - Balestrazzi, Emilio

PY - 2011

Y1 - 2011

N2 - PURPOSE: To report 3 cases of stromal rejection after deep anterior lamellar keratoplasty (DALK) assisted by a femtosecond laser. METHODS: Three keratoconus eyes of 2 men (22 and 30 years old) and 1 woman (24 years old) who had DALK with a 60-kHz femtosecond laser developed intrastromal graft rejection with superficial and deep neovascularization after 6, 15, and 12 months, respectively. All patients underwent confocal microscopy and were treated with topical steroid therapy. RESULTS: In vivo confocal microscopy revealed cellular inflammatory infiltrates in the subepithelial and middle stroma of the donor lamella without involvement of the endothelium. Graft rejection was rapidly reversed with topical steroid therapy, and a clear cornea was restored in all cases. CONCLUSIONS: Graft rejection remains a significant complication of lamellar surgery but is associated with good tissue restoration and complete visual recovery.

AB - PURPOSE: To report 3 cases of stromal rejection after deep anterior lamellar keratoplasty (DALK) assisted by a femtosecond laser. METHODS: Three keratoconus eyes of 2 men (22 and 30 years old) and 1 woman (24 years old) who had DALK with a 60-kHz femtosecond laser developed intrastromal graft rejection with superficial and deep neovascularization after 6, 15, and 12 months, respectively. All patients underwent confocal microscopy and were treated with topical steroid therapy. RESULTS: In vivo confocal microscopy revealed cellular inflammatory infiltrates in the subepithelial and middle stroma of the donor lamella without involvement of the endothelium. Graft rejection was rapidly reversed with topical steroid therapy, and a clear cornea was restored in all cases. CONCLUSIONS: Graft rejection remains a significant complication of lamellar surgery but is associated with good tissue restoration and complete visual recovery.

KW - femtosecond laser

KW - graft rejection

KW - lamellar keratoplasty

KW - femtosecond laser

KW - graft rejection

KW - lamellar keratoplasty

UR - http://hdl.handle.net/10807/10568

UR - http://www.corneajrnl.com/

M3 - Article

SN - 0277-3740

SP - 912

EP - 916

JO - Cornea

JF - Cornea

ER -

Graft rejection after femtosecond laser-assisted deep anterior lamellar keratoplasty: report of 3 cases.

Abstract

Keywords

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