Golimumab in patients affected by moderate to severe psoriatic arthritis: An open-label study in thirty-two patients previously treated with other biologics

Maria Sole Chimenti, Miriam Teoli, Rosita Saraceno, Annunziata Dattola, Alessandra Ventura, Andrea Chiricozzi, Carlo Chiaramonte, Roberto Perricone, Sergio Chimenti

Research output: Contribution to journalArticle

Abstract

Background: Clinical trials have demonstrated the efficacy of golimumab (GLB) in improving the signs and symptoms of psoriatic arthritis (PsA). Objective: The aim of this study was to evaluate the efficacy of GLB in monotherapy in patients affected by PsA with cutaneous involvement unresponsive to other anti-tumor necrosis factor-α (TNF-α) agents. Methods: This study included 32 patients treated with GLB as monotherapy, at a dosage of 50 mg, subcutaneously, every 4 weeks. Patients were divided into 3 groups (A, B, and C) according to their number of previous anti-TNF-α treatments (1, 2, or 3). Clinical and laboratory evaluations were performed at weeks 0, 12, and 24. Results: All patients showed significant improvement of their clinical, inflammatory, and quality of life indexes. Conclusion: Data suggest that GLB can be successful and safe in patients affected by PsA with skin involvement previously treated with other anti-TNF-α agents. © 2013 S. Karger AG, Basel.
Original languageEnglish
Pages (from-to)305-310
Number of pages6
JournalDermatology
Volume227
DOIs
Publication statusPublished - 2014

Keywords

  • Golimumab
  • Monotherapy
  • Psoriasis
  • Psoriatic arthritis

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