GnRH test for the diagnosis of central precocious puberty: is it time to revisit the protocol?

The use of a simplified GnRH test with a single dose of LH assessed 30 minutes after GnRH agonist represents a valid alternative to the traditional test required for establishing the diagnosis of central precocious puberty. Although cost optimization and higher facilities for children are important issues, further confirmatory studies with larger populations of children suspected to have central precocious puberty will help confirming the effectiveness of this strategy.