Glucose toxicity: the leading actor in the pathogenesis and clinical history of type 2 diabetes - mechanisms and potentials for treatment

Andrea Giaccari; Gianpio Sorice; Giovanna Muscogiuri

doi:10.1016/j.numecd.2009.03.018

Glucose toxicity: the leading actor in the pathogenesis and clinical history of type 2 diabetes - mechanisms and potentials for treatment

Andrea Giaccari, Gianpio Sorice, Giovanna Muscogiuri

Research output: Contribution to journal › Article › peer-review

77 Citations (Scopus)

Abstract

Although it is now well established that the deleterious effects of chronic hyperglycaemia (i.e., glucose toxicity) play an important role in the progressive impairment of insulin secretion and sensitivity, the two major actors of the pathogenesis of type 2 diabetes mellitus, the precise biochemical and molecular mechanisms responsible for the defects induced by glucose toxicity still remain to be defined.

Original language	English
Pages (from-to)	365-377
Number of pages	13
Journal	NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
Volume	19
DOIs	https://doi.org/10.1016/j.numecd.2009.03.018
Publication status	Published - 2009

Keywords

Blood Glucose
Cardiovascular Diseases
Diabetes Complications
Diabetes Mellitus, Type 2
Hexosamines
Humans
Hyperglycemia
Hypoglycemic Agents
Insulin
Oxidative Stress
Protein Kinase C
Secondary Prevention

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10.1016/j.numecd.2009.03.018

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title = "Glucose toxicity: the leading actor in the pathogenesis and clinical history of type 2 diabetes - mechanisms and potentials for treatment",

abstract = "Although it is now well established that the deleterious effects of chronic hyperglycaemia (i.e., glucose toxicity) play an important role in the progressive impairment of insulin secretion and sensitivity, the two major actors of the pathogenesis of type 2 diabetes mellitus, the precise biochemical and molecular mechanisms responsible for the defects induced by glucose toxicity still remain to be defined.",

keywords = "Blood Glucose, Cardiovascular Diseases, Diabetes Complications, Diabetes Mellitus, Type 2, Hexosamines, Humans, Hyperglycemia, Hypoglycemic Agents, Insulin, Oxidative Stress, Protein Kinase C, Secondary Prevention, Blood Glucose, Cardiovascular Diseases, Diabetes Complications, Diabetes Mellitus, Type 2, Hexosamines, Humans, Hyperglycemia, Hypoglycemic Agents, Insulin, Oxidative Stress, Protein Kinase C, Secondary Prevention",

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T1 - Glucose toxicity: the leading actor in the pathogenesis and clinical history of type 2 diabetes - mechanisms and potentials for treatment

AU - Giaccari, Andrea

AU - Sorice, Gianpio

AU - Muscogiuri, Giovanna

PY - 2009

Y1 - 2009

N2 - Although it is now well established that the deleterious effects of chronic hyperglycaemia (i.e., glucose toxicity) play an important role in the progressive impairment of insulin secretion and sensitivity, the two major actors of the pathogenesis of type 2 diabetes mellitus, the precise biochemical and molecular mechanisms responsible for the defects induced by glucose toxicity still remain to be defined.

AB - Although it is now well established that the deleterious effects of chronic hyperglycaemia (i.e., glucose toxicity) play an important role in the progressive impairment of insulin secretion and sensitivity, the two major actors of the pathogenesis of type 2 diabetes mellitus, the precise biochemical and molecular mechanisms responsible for the defects induced by glucose toxicity still remain to be defined.

KW - Blood Glucose

KW - Cardiovascular Diseases

KW - Diabetes Complications

KW - Diabetes Mellitus, Type 2

KW - Hexosamines

KW - Humans

KW - Hyperglycemia

KW - Hypoglycemic Agents

KW - Insulin

KW - Oxidative Stress

KW - Protein Kinase C

KW - Secondary Prevention

KW - Blood Glucose

KW - Cardiovascular Diseases

KW - Diabetes Complications

KW - Diabetes Mellitus, Type 2

KW - Hexosamines

KW - Humans

KW - Hyperglycemia

KW - Hypoglycemic Agents

KW - Insulin

KW - Oxidative Stress

KW - Protein Kinase C

KW - Secondary Prevention

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UR - http://www.nmcd-journal.com/article/s0939-4753(09)00069-6/abstract

U2 - 10.1016/j.numecd.2009.03.018

DO - 10.1016/j.numecd.2009.03.018

M3 - Article

VL - 19

SP - 365

EP - 377

JO - NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

JF - NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

SN - 0939-4753

ER -

Glucose toxicity: the leading actor in the pathogenesis and clinical history of type 2 diabetes - mechanisms and potentials for treatment

Abstract

Keywords

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