Abstract
Although it is now well established that the deleterious effects of chronic hyperglycaemia (i.e., glucose toxicity) play an important role in the progressive impairment of insulin secretion and sensitivity, the two major actors of the pathogenesis of type 2 diabetes mellitus, the precise biochemical and molecular mechanisms responsible for the defects induced by glucose toxicity still remain to be defined.
Original language | English |
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Pages (from-to) | 365-377 |
Number of pages | 13 |
Journal | NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES |
Volume | 19 |
DOIs | |
Publication status | Published - 2009 |
Keywords
- Blood Glucose
- Cardiovascular Diseases
- Diabetes Complications
- Diabetes Mellitus, Type 2
- Hexosamines
- Humans
- Hyperglycemia
- Hypoglycemic Agents
- Insulin
- Oxidative Stress
- Protein Kinase C
- Secondary Prevention