Glucose toxicity: the leading actor in the pathogenesis and clinical history of type 2 diabetes - mechanisms and potentials for treatment

Andrea Giaccari, Gianpio Sorice, Giovanna Muscogiuri

Research output: Contribution to journalArticlepeer-review

77 Citations (Scopus)

Abstract

Although it is now well established that the deleterious effects of chronic hyperglycaemia (i.e., glucose toxicity) play an important role in the progressive impairment of insulin secretion and sensitivity, the two major actors of the pathogenesis of type 2 diabetes mellitus, the precise biochemical and molecular mechanisms responsible for the defects induced by glucose toxicity still remain to be defined.
Original languageEnglish
Pages (from-to)365-377
Number of pages13
JournalNMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
Volume19
DOIs
Publication statusPublished - 2009

Keywords

  • Blood Glucose
  • Cardiovascular Diseases
  • Diabetes Complications
  • Diabetes Mellitus, Type 2
  • Hexosamines
  • Humans
  • Hyperglycemia
  • Hypoglycemic Agents
  • Insulin
  • Oxidative Stress
  • Protein Kinase C
  • Secondary Prevention

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