Glucokinase regulatory protein gene polymorphism affects liver fibrosis in non-alcoholic fatty liver disease

Salvatore Petta, Luca Miele, Elisabetta Bugianesi, Calogero Cammà, Chiara Rosso, Stefania Boccia, Daniela Cabibi, Vito Di Marco, Stefania Grimaudo, Antonio Grieco, Rosaria Maria Pipitone, Giulio Marchesini, Antonio Craxì

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Variant in glucokinase regulatory protein (GCKR), associated with lipid and glucose traits, has been suggested to affect fatty liver infiltration. We aimed to assess whether GCKR rs780094 C→T SNP influences the expression of steatosis, lobular inflammation and fibrosis in NAFLD patients, after correction for PNPLA3 genotype.
Original languageEnglish
Pages (from-to)e87523-e87523
JournalPLoS One
Volume9
DOIs
Publication statusPublished - 2014

Keywords

  • GENETICS
  • GLUCKINASE
  • LIVER FIBROSIS
  • NAFLD

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