Genome-wide expression profiling of the response to short-term exposure to fluconazole in Cryptococcus neoformans serotype A

Giovanni Fadda, Maurizio Sanguinetti, Brunella Posteraro, Elena De Carolis, Riccardo Torelli, Selene Ferrari, Dominique Sanglard

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Fluconazole (FLC), a triazole antifungal drug, is widely used for the maintenance therapy of cryptococcal meningoencephalitis, the most common opportunistic infection in AIDS patients. In this study, we examined changes in the gene expression profile of the C. neoformans reference strain H99 (serotype A) following FLC treatment in order to investigate the adaptive cellular responses to drug stress.
Original languageEnglish
Pages (from-to)97-97
Number of pages13
JournalBMC Microbiology
Volume11
DOIs
Publication statusPublished - 2011

Keywords

  • Antifungal Agents
  • Cryptococcus neoformans
  • Fluconazole
  • Gene Expression Profiling
  • Gene Expression Regulation, Fungal
  • Humans
  • Stress, Physiological

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