Genome-wide expression profiling of the response to short-term exposure to fluconazole in Cryptococcus neoformans serotype A

Ada Rita Florio; Selene Ferrari; Elena De Carolis; Riccardo Torelli; Giovanni Fadda; Maurizio Sanguinetti; Dominique Sanglard; Brunella Posteraro

doi:10.1186/1471-2180-11-97

Genome-wide expression profiling of the response to short-term exposure to fluconazole in Cryptococcus neoformans serotype A

Ada Rita Florio, Selene Ferrari, Elena De Carolis, Riccardo Torelli, Giovanni Fadda, Maurizio Sanguinetti, Dominique Sanglard, Brunella Posteraro

University of Lausanne

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Fluconazole (FLC), a triazole antifungal drug, is widely used for the maintenance therapy of cryptococcal meningoencephalitis, the most common opportunistic infection in AIDS patients. In this study, we examined changes in the gene expression profile of the C. neoformans reference strain H99 (serotype A) following FLC treatment in order to investigate the adaptive cellular responses to drug stress.

Original language	English
Pages (from-to)	97-97
Number of pages	13
Journal	BMC Microbiology
Volume	11
DOIs	https://doi.org/10.1186/1471-2180-11-97
Publication status	Published - 2011

Keywords

Antifungal Agents
Cryptococcus neoformans
Fluconazole
Gene Expression Profiling
Gene Expression Regulation, Fungal
Humans
Stress, Physiological

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/1471-2180-11-97

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title = "Genome-wide expression profiling of the response to short-term exposure to fluconazole in Cryptococcus neoformans serotype A",

abstract = "Fluconazole (FLC), a triazole antifungal drug, is widely used for the maintenance therapy of cryptococcal meningoencephalitis, the most common opportunistic infection in AIDS patients. In this study, we examined changes in the gene expression profile of the C. neoformans reference strain H99 (serotype A) following FLC treatment in order to investigate the adaptive cellular responses to drug stress.",

keywords = "Antifungal Agents, Cryptococcus neoformans, Fluconazole, Gene Expression Profiling, Gene Expression Regulation, Fungal, Humans, Stress, Physiological, Antifungal Agents, Cryptococcus neoformans, Fluconazole, Gene Expression Profiling, Gene Expression Regulation, Fungal, Humans, Stress, Physiological",

author = "Florio, {Ada Rita} and Selene Ferrari and {De Carolis}, Elena and Riccardo Torelli and Giovanni Fadda and Maurizio Sanguinetti and Dominique Sanglard and Brunella Posteraro",

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T1 - Genome-wide expression profiling of the response to short-term exposure to fluconazole in Cryptococcus neoformans serotype A

AU - Florio, Ada Rita

AU - Ferrari, Selene

AU - De Carolis, Elena

AU - Torelli, Riccardo

AU - Fadda, Giovanni

AU - Sanguinetti, Maurizio

AU - Sanglard, Dominique

AU - Posteraro, Brunella

PY - 2011

Y1 - 2011

N2 - Fluconazole (FLC), a triazole antifungal drug, is widely used for the maintenance therapy of cryptococcal meningoencephalitis, the most common opportunistic infection in AIDS patients. In this study, we examined changes in the gene expression profile of the C. neoformans reference strain H99 (serotype A) following FLC treatment in order to investigate the adaptive cellular responses to drug stress.

AB - Fluconazole (FLC), a triazole antifungal drug, is widely used for the maintenance therapy of cryptococcal meningoencephalitis, the most common opportunistic infection in AIDS patients. In this study, we examined changes in the gene expression profile of the C. neoformans reference strain H99 (serotype A) following FLC treatment in order to investigate the adaptive cellular responses to drug stress.

KW - Antifungal Agents

KW - Cryptococcus neoformans

KW - Fluconazole

KW - Gene Expression Profiling

KW - Gene Expression Regulation, Fungal

KW - Humans

KW - Stress, Physiological

KW - Antifungal Agents

KW - Cryptococcus neoformans

KW - Fluconazole

KW - Gene Expression Profiling

KW - Gene Expression Regulation, Fungal

KW - Humans

KW - Stress, Physiological

UR - http://hdl.handle.net/10807/2663

U2 - 10.1186/1471-2180-11-97

DO - 10.1186/1471-2180-11-97

M3 - Article

SN - 1471-2180

VL - 11

SP - 97

EP - 97

JO - BMC Microbiology

JF - BMC Microbiology

ER -

Genome-wide expression profiling of the response to short-term exposure to fluconazole in Cryptococcus neoformans serotype A

Abstract

Keywords

UN SDGs

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