Genetics of lipedema: new perspectives on genetic research and molecular diagnoses

Pietro Chiurazzi, S. Paolacci, V. Precone, F. Acquaviva, E. Fulcheri, M. Pinelli, F. Buffelli, S. Michelini, K. L. Herbst, V. Unfer, M. Bertelli

Research output: Contribution to journalArticle

10 Citations (Scopus)


OBJECTIVE: The aim of this qualitative review is to provide an update on the current understanding of the genetic determinants of lipedema and to develop a genetic test to differentiate lipedema from other diagnoses.MATERIALS AND METHODS: An electronic search was conducted in MEDLINE, PubMed, and Scopus for articles published in English up to March 2019. Lipedema and similar disorders included in the differential diagnosis of lipedema were searched in the clinical synopsis section of OMIM, in GeneCards, Orphanet, and MalaCards.RESULTS: The search identified several genetic factors related to the onset of lipedema and highlighted the utility of developing genetic diagnostic testing to help differentiate lipedema from other diagnoses.CONCLUSIONS: No genetic tests or guidelines for molecular diagnosis of lipedema are currently available, despite the fact that genetic testing is fundamental for the differential diagnosis of lipedema against Mendelian genetic obesity, primary lymphedema, and lipodystrophies.
Original languageEnglish
Pages (from-to)5581-5594
Number of pages14
JournalEuropean Review for Medical and Pharmacological Sciences
Publication statusPublished - 2019


  • Differential diagnosis
  • Genetic diagnosis
  • Lipedema
  • Lipoedema
  • Subcutaneous fat


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