Gene profiling of bone marrow- and adipose tissue-derived stromal cells: a key role of Kruppel-like factor 4 in cell fate regulation

Wanda Lattanzi, Giovambattista Pani, Sergio Alfieri, Antonio Gasbarrini, Nathalie Saulnier, Maria Ausiliatrice Puglisi, Giuseppe Leone, Fabrizio Michetti, L Castellini, Ac Piscaglia

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Bone marrow- and adipose tissue-derived mesenchymal stromal cells (MSC) represent promising sources for regenerative medicine. However, the precise molecular mechanisms underlying MSC stemness maintenance versus differentiation are not fully understood. The aim of this study was to compare the genome-wide expression profiles of bone marrow-and adipose tissue-derived MSC, in order to identify a common molecular stemness core.
Original languageEnglish
Pages (from-to)329-340
Number of pages12
JournalCytotherapy
Volume13
DOIs
Publication statusPublished - 2011

Keywords

  • Adipose Tissue
  • Adult
  • Binding Sites
  • Bone Marrow Cells
  • Cell Differentiation
  • Cell Lineage
  • Chromatin Immunoprecipitation
  • Female
  • Gene Expression Profiling
  • Gene Expression Regulation
  • Gene Knockdown Techniques
  • Humans
  • Kruppel-Like Transcription Factors
  • Male
  • Mesenchymal Stem Cells
  • Middle Aged
  • Models, Biological
  • Polymerase Chain Reaction
  • Promoter Regions, Genetic
  • Protein Binding
  • Reproducibility of Results
  • Stromal Cells
  • Young Adult

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