Gastroenteropancreatic (neuro)endocrine neoplasms: the histology report

Guido Rindi; C Bordi; S La Rosa; E Solcia; G. Delle Fave

doi:10.1016/S1590-8658(11)60591-4

Gastroenteropancreatic (neuro)endocrine neoplasms: the histology report

Guido Rindi, C Bordi, S La Rosa, E Solcia, G. Delle Fave

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50 Citations (SciVal)

Abstract

Based on the year 2000 World Health Organization (WHO) classification and the European Neuroendocrine Tumor Society (ENETS) grading and staging proposals, we here define the minimal guidelines for pathology reporting of (neuro)endocrine neoplasms. The macroscopical description is recommended according to standard procedures and the microscopical description according to recognized architectural and cytological features for endocrine lesions. Minimal diagnostic immunohistochemistry entails the use of chromogranin A, synaptophysin and Ki67. Other potentially useful tests are those for CD56 N-CAM, PGP 9.5 and hormones for diagnosis, the somatostatin receptor subtype 2 for potential radiodiagnostics and therapy, and transcription factors like TTF1 and CDX2, for site of origin. Grading definition is always mandatory as well as TNM staging for surgical specimens.

Original language	English
Pages (from-to)	S356-S356-60
Journal	Digestive and Liver Disease
DOIs	https://doi.org/10.1016/S1590-8658(11)60591-4
Publication status	Published - 2011

Keywords

Carcinoma, Neuroendocrine
Digestive System Neoplasms
Humans
Neoplasm Staging
Neuroendocrine Tumors
Pathology

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10.1016/S1590-8658(11)60591-4

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title = "Gastroenteropancreatic (neuro)endocrine neoplasms: the histology report",

abstract = "Based on the year 2000 World Health Organization (WHO) classification and the European Neuroendocrine Tumor Society (ENETS) grading and staging proposals, we here define the minimal guidelines for pathology reporting of (neuro)endocrine neoplasms. The macroscopical description is recommended according to standard procedures and the microscopical description according to recognized architectural and cytological features for endocrine lesions. Minimal diagnostic immunohistochemistry entails the use of chromogranin A, synaptophysin and Ki67. Other potentially useful tests are those for CD56 N-CAM, PGP 9.5 and hormones for diagnosis, the somatostatin receptor subtype 2 for potential radiodiagnostics and therapy, and transcription factors like TTF1 and CDX2, for site of origin. Grading definition is always mandatory as well as TNM staging for surgical specimens.",

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author = "Guido Rindi and C Bordi and {La Rosa}, S and E Solcia and {Delle Fave}, G.",

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doi = "10.1016/S1590-8658(11)60591-4",

language = "English",

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AU - Rindi, Guido

AU - Bordi, C

AU - La Rosa, S

AU - Solcia, E

AU - Delle Fave, G.

PY - 2011

Y1 - 2011

N2 - Based on the year 2000 World Health Organization (WHO) classification and the European Neuroendocrine Tumor Society (ENETS) grading and staging proposals, we here define the minimal guidelines for pathology reporting of (neuro)endocrine neoplasms. The macroscopical description is recommended according to standard procedures and the microscopical description according to recognized architectural and cytological features for endocrine lesions. Minimal diagnostic immunohistochemistry entails the use of chromogranin A, synaptophysin and Ki67. Other potentially useful tests are those for CD56 N-CAM, PGP 9.5 and hormones for diagnosis, the somatostatin receptor subtype 2 for potential radiodiagnostics and therapy, and transcription factors like TTF1 and CDX2, for site of origin. Grading definition is always mandatory as well as TNM staging for surgical specimens.

AB - Based on the year 2000 World Health Organization (WHO) classification and the European Neuroendocrine Tumor Society (ENETS) grading and staging proposals, we here define the minimal guidelines for pathology reporting of (neuro)endocrine neoplasms. The macroscopical description is recommended according to standard procedures and the microscopical description according to recognized architectural and cytological features for endocrine lesions. Minimal diagnostic immunohistochemistry entails the use of chromogranin A, synaptophysin and Ki67. Other potentially useful tests are those for CD56 N-CAM, PGP 9.5 and hormones for diagnosis, the somatostatin receptor subtype 2 for potential radiodiagnostics and therapy, and transcription factors like TTF1 and CDX2, for site of origin. Grading definition is always mandatory as well as TNM staging for surgical specimens.

KW - Carcinoma, Neuroendocrine

KW - Digestive System Neoplasms

KW - Humans

KW - Neoplasm Staging

KW - Neuroendocrine Tumors

KW - Pathology

KW - Carcinoma, Neuroendocrine

KW - Digestive System Neoplasms

KW - Humans

KW - Neoplasm Staging

KW - Neuroendocrine Tumors

KW - Pathology

UR - http://hdl.handle.net/10807/5869

U2 - 10.1016/S1590-8658(11)60591-4

DO - 10.1016/S1590-8658(11)60591-4

M3 - Article

SN - 1590-8658

SP - S356-S356-60

JO - Digestive and Liver Disease

JF - Digestive and Liver Disease

ER -

Gastroenteropancreatic (neuro)endocrine neoplasms: the histology report

Abstract

Keywords

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