Gambling behavior in Parkinson's Disease: impulsivity, reward mechanism and cortical brain oscillations

Michela Balconi, Laura Angioletti, Chiara Siri, Nicoletta Meucci, Gianni Pezzoli

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Psychopathological components, such as reward sensitivity and impulsivity, and dopaminergic treatment are crucial characteristics related to the development of Pathological Gambling (PG) in Parkinson's Disease (PD). The aim of the present study is to investigate the differences in decision-making in PD patients with or without PG considering both neurophysiological and behavioral aspects. The IOWA Gambling Task (IGT) and electroencephalographic (EEG) activity were considered to elucidate the decision and post-feedback processes in PG. The sample included fifty-two PD patients, divided in three groups: 17 PD patients with active gambling behavior (PD Gamblers, PDG); 15 PD patients who remitted from PG (PD Non-Gamblers, PDNG); and a Control Group (CG) composed by 20 patients with PD only. EEG and IGT performance were recorded during decision and post-feedback phase. Results showed worse performance and an increase of the low frequency bands in the frontal area for the PDG group compared to the other two groups. In addition, higher BAS (Behavioral Activation System) and BIS-11 (Barratt Impulsiveness Scale) personality components were correlated to groups’ behavioral response. These results show an anomalous behavioral (IGT) and cortical response of PDG patients related to their inability to use adequate control mechanisms during a decision-making task where reward mechanisms (BAS) and impulsivity (BIS-11) are relevant.
Original languageEnglish
Pages (from-to)974-980
Number of pages7
JournalPsychiatry Research
Volume270
DOIs
Publication statusPublished - 2018

Keywords

  • Decision making
  • Electroencephalography (EEG)
  • Iowa Gambling Task
  • Parkinson's Disease
  • Pathological gambling

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