TY - JOUR
T1 - Functional and morphologic findings at four years after intravitreal bevacizumab or laser for type 1 ROP
AU - Lepore, Domenico
AU - Ji, Marco H.
AU - Quinn, Graham E.
AU - Amorelli, Giulia Maria
AU - Orazi, Lorenzo
AU - Ricci, Daniela
AU - Mercuri, Eugenio Maria
PY - 2020
Y1 - 2020
N2 - BACKGROUND AND OBJECTIVE: To compare morphologic and functional status at age 4 years for patients treated in one eye with laser photocoagulation and the other eye with intravitreal bevacizumab (IVB) injection for Type 1 retinopathy of prematurity (ROP). PATIENTS AND METHODS: In this single-center, randomized, controlled trial, best-corrected visual acuity (BCVA) in logMAR was obtained along with spherical equivalent refraction (SER), fluorescein angiography (FA), optical coherent tomography (OCT), and OCT angiography (OCTA). RESULTS: Eighteen babies (36 eyes) were selected for this study. BCVA and SER were similar in the two groups, but six patients had anisometropia of 4 diopters or more. IVB-treated eyes tended to have thinner foveal thickness than laser-treated eyes (mean difference: –5.33 pixels; 95% confidence interval, –9.62 to –1.05). CONCLUSION: Although the differences found here are minimal between the IVB-treated and laser-treated groups, further long-term evaluation of not only FA, but also OCT and OCTA, are needed in larger studies.
AB - BACKGROUND AND OBJECTIVE: To compare morphologic and functional status at age 4 years for patients treated in one eye with laser photocoagulation and the other eye with intravitreal bevacizumab (IVB) injection for Type 1 retinopathy of prematurity (ROP). PATIENTS AND METHODS: In this single-center, randomized, controlled trial, best-corrected visual acuity (BCVA) in logMAR was obtained along with spherical equivalent refraction (SER), fluorescein angiography (FA), optical coherent tomography (OCT), and OCT angiography (OCTA). RESULTS: Eighteen babies (36 eyes) were selected for this study. BCVA and SER were similar in the two groups, but six patients had anisometropia of 4 diopters or more. IVB-treated eyes tended to have thinner foveal thickness than laser-treated eyes (mean difference: –5.33 pixels; 95% confidence interval, –9.62 to –1.05). CONCLUSION: Although the differences found here are minimal between the IVB-treated and laser-treated groups, further long-term evaluation of not only FA, but also OCT and OCTA, are needed in larger studies.
KW - Retinopathy of Prematurity
KW - Retinopathy of Prematurity
UR - http://hdl.handle.net/10807/172070
U2 - 10.3928/23258160-20200228-07
DO - 10.3928/23258160-20200228-07
M3 - Article
SN - 1542-8877
VL - 51
SP - 180
EP - 186
JO - Ophthalmic Surgery Lasers and Imaging
JF - Ophthalmic Surgery Lasers and Imaging
ER -