TY - JOUR
T1 - From bone marrow to the arterial wall: the ongoing tale of endothelial progenitor cells
AU - Leone, Antonio Maria
AU - Valgimigli, Massimo
AU - Giannico, Maria Benedetta
AU - Zaccone, Vincenzo
AU - Perfetti, Matteo
AU - D'Amario, Domenico
AU - Rebuzzi, Antonio Giuseppe
AU - Crea, Filippo
PY - 2009
Y1 - 2009
N2 - Several physiological and pathophysiological stimuli or drugs modulate endothelial progenitor cell (EPC) mobilization. Moreover, levels of circulating EPCs predict cardiovascular risk and left ventricular remodelling after myocardial infarction. Nevertheless, our understanding in this field is complicated by lack of an unequivocal definition of EPCs, thus limiting their clinical applications. This review summarizes current knowledge and uncertainties on EPC characterization and mobilization in the attempt to define their role in the management of cardiovascular diseases.
AB - Several physiological and pathophysiological stimuli or drugs modulate endothelial progenitor cell (EPC) mobilization. Moreover, levels of circulating EPCs predict cardiovascular risk and left ventricular remodelling after myocardial infarction. Nevertheless, our understanding in this field is complicated by lack of an unequivocal definition of EPCs, thus limiting their clinical applications. This review summarizes current knowledge and uncertainties on EPC characterization and mobilization in the attempt to define their role in the management of cardiovascular diseases.
KW - endothelial progenitor cell
KW - endothelial progenitor cell
UR - http://hdl.handle.net/10807/29103
U2 - 10.1093/eurheartj/ehp078
DO - 10.1093/eurheartj/ehp078
M3 - Article
SN - 0195-668X
SP - 890
EP - 899
JO - European Heart Journal
JF - European Heart Journal
ER -
