Fractional Flow Reserve–Based Coronary Artery Bypass Surgery: Current Evidence and Future Directions

Cristiano Spadaccio, David Glineur, Emanuele Barbato, Antonino Di Franco, Keith G. Oldroyd, Giuseppe Biondi-Zoccai, Filippo Crea, Stephen E. Fremes, Dominick J. Angiolillo, Mario Fulvio Luigi Gaudino

Research output: Contribution to journalArticle

10 Citations (Scopus)


Fractional flow reserve (FFR) provides an objective measurement of the severity of ischemia caused by coronary stenoses in downstream myocardial regions. Data from the interventional cardiology realm have suggested benefits of a FFR-guided percutaneous coronary intervention (PCI) strategy. Limited evidence is available on the use of FFR to guide coronary artery bypass grafting (CABG). The most recent data have shown that FFR might simplify CABG procedures and optimize patency of arterial grafts without any clear impact on clinical outcomes. The aim of this review was to summarize the available data on FFR-based CABG and discuss the rationale and potential consequences of a switch toward FFR-based surgical revascularization strategy.
Original languageEnglish
Pages (from-to)1086-1096
Number of pages11
JournalJACC: Cardiovascular Interventions
Publication statusPublished - 2020


  • CABG
  • Cardiac Catheterization
  • Coronary Angiography
  • Coronary Artery Bypass
  • Coronary Artery Disease
  • FFR
  • Fractional Flow Reserve, Myocardial
  • Humans
  • Predictive Value of Tests
  • Treatment Outcome
  • Vascular Patency
  • myocardial revascularization


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