FOXP2, APOE, and PRNP: New Modulators in Primary Progressive Aphasia

Carlo Masullo, Antonio Daniele, Enrico Premi, Andrea Pilotto, Antonella Alberici, Alice Papetti, Silvana Archetti, Davide Seripa, Valentina Garibotto, Barbara Paghera, Federico Caobelli, Alessandro Padovani, Barbara Borroni

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Primary progressive aphasia (PPA) is a heterogeneous disorder characterized by progressive language impairment.Polymorphisms within forkhead box P2 gene (FOXP2) gene have been associated with speech and language impairment. Apolipoprotein E (APOE) genotype and PRNP 129 codon status have been demonstrated to increase the risk of PPA, but with contrasting results. In the present study, we have evaluated the impact of FOXP2, APOE and PRNP genetic variations as risk factors and/or disease-modulators in PPA. 94 PPA patients and 200 age-matched healthy controls were considered and FOXP2 polymorphisms (rs1456031, rs17137124), APOE genotype, and PRNP codon 129 polymorphism analyzed. In 34 PPA patients, SPECT imaging data were analyzed by Statistical Parametric Mapping (SPM8). Genetic distributions and allele frequencies of FOXP2 and PRNP polymorphisms did not differ between groups while APOE 4 was more represented in PPA as compared to controls. PPA patients carrying at-risk FOXP2 polymorphisms (rs1456031 and/or rs17137124) showed greater hypoperfusion in the frontal areas, namely the left inferior frontal gyrus and the right cingulated gyrus compared to non-carriers (p < 0.005). PPA patients carrying at least one 4 allele had greater hypoperfusion in orbitofrontal regions (superior frontal gyrus and orbital gyrus) as compared to non-carriers 4 (p < 0.005). PRNP codon 129 homozygosity correlated with left frontotemporal hypoperfusion (p < 0.005). Genetic variations within FOXP2, APOE, and PRNP modulate PPA disease, leading to a specific regional hypoperfusion according to different molecular pathways. APOE 4 is overrepresented in PPA, thus likely acting as genetic risk factor on disease development.
Original languageEnglish
Pages (from-to)941-950
Number of pages10
JournalJournal of Alzheimer's Disease
Publication statusPublished - 2012


  • Apolipoprotein E4
  • FOXP2
  • Primary progressive aphasia

Fingerprint Dive into the research topics of 'FOXP2, APOE, and PRNP: New Modulators in Primary Progressive Aphasia'. Together they form a unique fingerprint.

Cite this