Focusing in multiwell potentials: Applications to ion channels

Fausto Borgonovi, Luca Ponzoni, Giuseppe Celardo, G. L. Celardo, L. Kaplan, A. Kargol

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

We investigate nonequilibrium stationary distributions induced by stochastic dichotomous noise in double-well and multiwell models of ion channel gating kinetics. The channel kinetics is analyzed using both overdamped Langevin equations and master equations. With the Langevin equation approach we show a nontrivial focusing effect due to the external stochastic noise, namely, the concentration of the probability distribution in one of the two wells of a double-well system or in one or more of the wells of the multiwell model. In the multiwell system, focusing in the outer wells is shown to be achievable under physiological conditions, while focusing in the central wells has proved possible so far only at very low temperatures. We also discuss the strength of the focusing effect and obtain the conditions necessary for maximal focusing to appear. These conditions cannot be predicted by a simple master equation approach.
Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalPHYSICAL REVIEW E, STATISTICAL, NONLINEAR, AND SOFT MATTER PHYSICS
Volume87
DOIs
Publication statusPublished - 2013

Keywords

  • classical transport
  • ion channels

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