Flupirtina Analgesico non oppiaceo ad azione centrale, capostipite di una nuova classe di analgesici (SNEPCO)

Translated title of the contribution: [Autom. eng. transl.] Flupirtine Non-opioid analgesic with central action, progenitor of a new class of analgesics (SNEPCO)

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

[Autom. eng. transl.] Flupirtine maleate, a molecule belonging to the class of triaminopiridine, has recently been marketed in Italy. Thanks to its analgesic and muscle relaxant properties, widely demonstrated by studies in animal models and in humans, flupirtine has been used for years, particularly in Germany, for the control of various forms of mild to moderate intensity, especially if associated with tension muscle. Flupirtine acts according to a different mechanism than the analgesics currently in use. The numerous studies conducted to define the mechanism of action have clearly shown that flupirtine is active at central level, but does not interact with opiate receptors. More recent studies have identified the potassium neuronal channels as the target of flupirtine which, by binding to the G protein associated with the channels, causes them to open and consequently reduce the conduction of the nerve impulse with repolarization of the membrane. Flupirtine is the forefather of the class of substances known today as selective activators of neuronal potassium or SNEPCO channels (selective neuronal potassium channel openers). The broad spectrum and the peculiar mechanism of action make this non-opioid analgesic, with central action, an interesting and additional therapeutic weapon for pain therapy, in particular when associated with muscle tension
Translated title of the contribution[Autom. eng. transl.] Flupirtine Non-opioid analgesic with central action, progenitor of a new class of analgesics (SNEPCO)
Original languageItalian
Title of host publicationFlupirtina Analgesico non oppiaceo ad azione centrale, capostipite di una nuova classe di analgesici (SNEPCO)
Pages1-15
Number of pages15
Publication statusPublished - 2009

Publication series

NameIN FOCUS

Keywords

  • ANALGESIA
  • FLUPIRTINA
  • SNEPCO

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