Flow Cytofluorimetric Analysis of Anti-LRP4 (LDL Receptor-Related Protein 4) Autoantibodies in Italian Patients with Myasthenia Gravis

Mariapaola Marino, Mario Sabatelli, Giovambattista Pani, Amelia Evoli, Flavia Scuderi, Daniela Maria Samengo, Emanuela Bartoccioni, Giorgia Saltelli, Chengyong Shen, Lin Mei, Giovanni Antonini

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Myasthenia gravis (MG) is an autoimmune disease in which 90% of patients have autoantibodies against the muscle nicotinic acetylcholine receptor (AChR), while autoantibodies to muscle-specific tyrosine kinase (MuSK) have been detected in half (5%) of the remaining 10%. Recently, the low-density lipoprotein receptor-related protein 4 (LRP4), identified as the agrin receptor, has been recognized as a third autoimmune target in a significant portion of the double sero-negative (dSN) myasthenic individuals, with variable frequency depending on different methods and origin countries of the tested population. There is also convincing experimental evidence that anti-LRP4 autoantibodies may cause MG.
Original languageEnglish
Pages (from-to)e0135378-e0135378
JournalPLoS One
Volume10
DOIs
Publication statusPublished - 2015

Keywords

  • autoantibody
  • autoimmunity

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