Fertility preservation in patients with BRCA mutations or Lynch syndrome

Giacomo Corrado; Claudia Marchetti; Rita Trozzi; Giovanni Scambia; Anna Fagotti

doi:10.1136/ijgc-2020-002071

Fertility preservation in patients with BRCA mutations or Lynch syndrome

Giacomo Corrado, Claudia Marchetti, Rita Trozzi, Giovanni Scambia, Anna Fagotti

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Abstract

Guidelines and expert consensus are lacking on fertility preservation in BRCA mutation carriers and in patients with Lynch syndrome. The safety of fertility preservation in this setting is still a topic of debate and multiple factors need to be carefully considered. The aim of this review was to analyze the reproductive potential of women harboring a genetic mutation affecting the DNA repair system and explore the efficacy and safety of existing fertility preservation strategies in these patients.

Original language	English
Pages (from-to)	332-338
Number of pages	7
Journal	International Journal of Gynecological Cancer
Volume	31
DOIs	https://doi.org/10.1136/ijgc-2020-002071
Publication status	Published - 2021

Keywords

BRCA1 protein
BRCA2 protein
lynch syndrome II

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title = "Fertility preservation in patients with BRCA mutations or Lynch syndrome",

abstract = "Guidelines and expert consensus are lacking on fertility preservation in BRCA mutation carriers and in patients with Lynch syndrome. The safety of fertility preservation in this setting is still a topic of debate and multiple factors need to be carefully considered. The aim of this review was to analyze the reproductive potential of women harboring a genetic mutation affecting the DNA repair system and explore the efficacy and safety of existing fertility preservation strategies in these patients.",

keywords = "BRCA1 protein, BRCA2 protein, lynch syndrome II, BRCA1 protein, BRCA2 protein, lynch syndrome II",

author = "Giacomo Corrado and Claudia Marchetti and Rita Trozzi and Giovanni Scambia and Anna Fagotti",

year = "2021",

doi = "10.1136/ijgc-2020-002071",

language = "English",

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T1 - Fertility preservation in patients with BRCA mutations or Lynch syndrome

AU - Corrado, Giacomo

AU - Marchetti, Claudia

AU - Trozzi, Rita

AU - Scambia, Giovanni

AU - Fagotti, Anna

PY - 2021

Y1 - 2021

N2 - Guidelines and expert consensus are lacking on fertility preservation in BRCA mutation carriers and in patients with Lynch syndrome. The safety of fertility preservation in this setting is still a topic of debate and multiple factors need to be carefully considered. The aim of this review was to analyze the reproductive potential of women harboring a genetic mutation affecting the DNA repair system and explore the efficacy and safety of existing fertility preservation strategies in these patients.

AB - Guidelines and expert consensus are lacking on fertility preservation in BRCA mutation carriers and in patients with Lynch syndrome. The safety of fertility preservation in this setting is still a topic of debate and multiple factors need to be carefully considered. The aim of this review was to analyze the reproductive potential of women harboring a genetic mutation affecting the DNA repair system and explore the efficacy and safety of existing fertility preservation strategies in these patients.

KW - BRCA1 protein

KW - BRCA2 protein

KW - lynch syndrome II

KW - BRCA1 protein

KW - BRCA2 protein

KW - lynch syndrome II

UR - http://hdl.handle.net/10807/178358

U2 - 10.1136/ijgc-2020-002071

DO - 10.1136/ijgc-2020-002071

M3 - Article

SN - 1048-891X

VL - 31

SP - 332

EP - 338

JO - International Journal of Gynecological Cancer

JF - International Journal of Gynecological Cancer

ER -

Fertility preservation in patients with BRCA mutations or Lynch syndrome

Abstract

Keywords

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