Fatal injection of ranitidine: A case report

Antonio Oliva, Vincenzo Arena, Fabio De Giorgio, Vincenzo Lorenzo Pascali, Sara Partemi, Catia Colecchi, Nadia Fucci

Research output: Contribution to journalArticle

Abstract

Introduction: Ranitidine hydrochloride (Zantac®), a histamine-2-receptor antagonist, is a widely used medication with an excellent safety record. Anaphylactic reaction to ranitidine is an extremely rare event and a related death has never been described in the literature. Case presentation: We present the clinical history, histological and toxicological data of a 51-year-old man with negative anamnesis for allergic events, who died suddenly after the intravenous administration of one phial of Zantac® 50 mg prescribed as a routine post-surgical prophylaxis for stress ulcer. Conclusion: Although the incidence of anaphylactic reactions related to ranitidine is low, caution needs to be exercised on administration of this drug. In addition, further study is needed to define strategies for the prevention of adverse drug reactions in hospitalized patients. © 2008 Oliva et al; licensee BioMed Central Ltd.
Original languageEnglish
Pages (from-to)232-232
Number of pages1
JournalJournal of Medical Case Reports
Volume2
DOIs
Publication statusPublished - 2008

Keywords

  • alfuzosin
  • anamnesis
  • anaphylactic shock
  • article
  • autopsy
  • blood toxicity
  • brain edema
  • case report
  • cefodizime
  • consciousness disorder
  • drug fatality
  • drug hypersensitivity
  • dyspnea
  • histopathology
  • hospital admission
  • human
  • hypotension
  • immediate type hypersensitivity
  • lung congestion
  • lung edema
  • male
  • petechia
  • prescription
  • priority journal
  • prostate hypertrophy
  • ranitidine, adult
  • stress ulcer
  • transurethral resection
  • wheezing

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