Failure of fibrinolytic endoventricular treatment to prevent neonatal post-haemorrhagic hydrocephalus. A case-control trial

Rita Paola Maria Luciano, Patrizia Papacci, Valerio De Stefano, Francesco Velardi, Costantino Romagnoli, Giuseppe Gio Batta Tortorolo

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Post-haemorrhagic hydrocephalus is assumed to result from obstruction of the cerebrospinal fluid (CSF) pathways by blood clots and subsequent chronic infiltration with collagen. The aim of this work was to evaluate the possibility of preventing permanent shunt dependence by enhancing the endoventricular fibrinolysis by means of an endoventricular streptokinase infusion in babies affected by posthaemorrhagic ventricular dilation. A case-control trial was carried out in 12 neonates affected by intraventricular haemorrhage and subsequent progressive ventriculomegaly. Six of them were treated with 20,000 U/day of streptokinase infused over 96 h through a percutaneous ventricular catheter. Our results show that the percentage of shunted babies was identical in treated and control patients despite the enhancement of endoventricular fibrinolysis obtained in all treated patients. On the basis of our results we do not recommend intraventricular streptokinase infusion for routine use in post-haemorrhagic ventricular dilatation.
Original languageEnglish
Pages (from-to)73-76
Number of pages4
JournalCHILDS NERVOUS SYSTEM
Volume13
Publication statusPublished - 1997

Keywords

  • Case-Control Studies
  • Cerebral Hemorrhage
  • Cerebral Ventricles
  • Female
  • Humans
  • Hydrocephalus
  • Infant, Newborn
  • Injections, Intraventricular
  • Male
  • Streptokinase
  • Thrombolytic Therapy
  • Treatment Failure
  • Ventriculoperitoneal Shunt

Fingerprint

Dive into the research topics of 'Failure of fibrinolytic endoventricular treatment to prevent neonatal post-haemorrhagic hydrocephalus. A case-control trial'. Together they form a unique fingerprint.

Cite this