Faecal microbiota transplantation for the treatment of diarrhoea induced by tyrosine-kinase inhibitors in patients with metastatic renal cell carcinoma

Gianluca Ianiro, Giovanni Schinzari, Luca Masucci, Maurizio Sanguinetti, Giampaolo Tortora, Antonio Gasbarrini, Giovanni Cammarota, Carlo Romano Settanni, Loris Riccardo Lopetuso, Roberto Iacovelli, Andrew M. Thomas, Federica Armanini, Aitor Blanco-Miguez, Francesco Asnicar, Clarissa Consolandi, Nicola Segata

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Diarrhoea is one of the most burdensome and common adverse events of chemotherapeutics, and has no standardised therapy to date. Increasing evidence suggests that the gut microbiome can influence the development of chemotherapy-induced diarrhoea. Here we report findings from a randomised clinical trial of faecal microbiota transplantation (FMT) to treat diarrhoea induced by tyrosine kinase inhibitors (TKI) in patients with metastatic renal cell carcinoma (ClinicalTrials.gov number: NCT04040712). The primary outcome is the resolution of diarrhoea four weeks after the end of treatments. Twenty patients are randomised to receive FMT from healthy donors or placebo FMT (vehicle only). Donor FMT is more effective than placebo FMT in treating TKI-induced diarrhoea, and a successful engraftment is observed in subjects receiving donor faeces. No serious adverse events are observed in both treatment arms. The trial meets pre-specified endpoints. Our findings suggest that the therapeutic manipulation of gut microbiota may become a promising treatment option to manage TKI-dependent diarrhoea.
Original languageEnglish
Pages (from-to)4333-N/A
JournalNature Communications
Volume11
DOIs
Publication statusPublished - 2020

Keywords

  • Aged
  • Carcinoma, Renal Cell
  • Diarrhea
  • Double-Blind Method
  • Drug Therapy
  • Dysbiosis
  • Enzyme Inhibitors
  • Fecal Microbiota Transplantation
  • Feces
  • Female
  • Gastrointestinal Microbiome
  • Humans
  • Kidney Neoplasms
  • Male
  • Middle Aged
  • Tissue Donors
  • Tyrosine

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