Expression of liquoral neuroprotection markers in children with acute lymphoblastic leukemia

Antonio Chiaretti, Antonio Ruggiero, Palma Maurizi, Paola Coccia, Alessia Antonelli, Filomena Pierri, Giovanni Barone, Giorgio Attina', Laura Iuvone, Riccardo Riccardi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Brain damage related to intrathecal methotrexate in children with acute lymphoblastic leukemia (ALL) is still unclear. Neuroinflammatory mechanisms and intracerebral production of specific biomarkers, play a key role in determining neuroprotective mechanisms after brain injury. To determine whether the CSF concentrations of neuron-specific enolase (NSE), neurotrophic factors and doublecortin (DCX) are influenced by repeated intrathecal methotrexate administrations, we prospectively collected CSF samples from 10 children with ALL and 10 controls. Our results showed an increased expression of the liquoral markers. This up-regulation could be interpreted as a neuroprotective response of the brain against the neuronal damages induced by MTX.
Original languageEnglish
Pages (from-to)1467-1471
Number of pages5
JournalLeukemia Research
Volume35
DOIs
Publication statusPublished - 2011

Keywords

  • Acute lymphoblastic leukemia
  • Children

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