Expression of c-myc in cutaneous lymphomas and pseudolymphomas

Ketty Peris, L Cerroni, H Kerl, T Radaszkiewicz, S Chimenti, H. Höfler

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The expression of the proto-oncogene c-myc was studied in tumorous skin lesions of (cutaneous) lymphoproliferative diseases (3 cases of pseudolymphoma, 8 cases of non-Hodgkin lymphoma and 1 case of lymph node involvement in mycosis fungoides) in a total of 12 patients. c-myc mRNA levels were quantified by Northern blot analysis followed by densitometric evaluation of the specific bands. Higher levels of c-myc mRNA expression were observed in lymphomas as compared with pseudolymphomas (p greater than 0.05). No significant differences in c-myc mRNA values were detected between B and T cell pseudolymphomas. Our results suggest that c-myc mRNA overexpression is associated with malignant lymphomas of the skin. We conclude that the measurement of c-myc mRNA levels may contribute to further characterize cutaneous lymphoproliferative diseases.
Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalDermatologica
Volume183
Publication statusPublished - 1991

Keywords

  • Blotting, Northern
  • Humans
  • Lymphoma
  • Proto-Oncogene Proteins c-myc
  • RNA, Messenger
  • Skin Neoplasms

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