Ex vivo gene therapy using autologous dermal fibroblasts expressing hLMP3 for rat mandibular bone regeneration

Claudio Parrilla; Wanda Lattanzi; A Rita Fetoni; Francesco Bussu; Enrico Pola; Gaetano Paludetti

doi:10.1002/hed.21185

Ex vivo gene therapy using autologous dermal fibroblasts expressing hLMP3 for rat mandibular bone regeneration

Claudio Parrilla^*
, Wanda Lattanzi
, A Rita Fetoni
, Francesco Bussu
, Enrico Pola
, Gaetano Paludetti

^*Corresponding author

Research output: Contribution to journal › Article

23 Citations (Scopus)

Abstract

Implantation of autologous skin fibroblasts transduced ex vivo with a replication-defective adenoviral vector, carrying the LIM mineralization protein-3 (Ad-LMP-3), and adsorbed on a hydroxyapatite/collagen (HA/COL) scaffold.

Original language	English
Pages (from-to)	310-318
Number of pages	9
Journal	HEAD & NECK
Volume	32
Issue number	3
DOIs	https://doi.org/10.1002/hed.21185
Publication status	Published - 2010

All Science Journal Classification (ASJC) codes

Otorhinolaryngology

Keywords

Animals
Biocompatible Materials
Bone Regeneration
Collagen
Dermis
Durapatite
Fibroblasts
Gene Therapy
Genetic
Guided Tissue Regeneration
Homeodomain Proteins
LIM-Homeodomain Proteins
Mandible
Osteogenesis
Rats
Tissue Scaffolds
Transcription Factors
Transduction
Wistar

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10.1002/hed.21185

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abstract = "Implantation of autologous skin fibroblasts transduced ex vivo with a replication-defective adenoviral vector, carrying the LIM mineralization protein-3 (Ad-LMP-3), and adsorbed on a hydroxyapatite/collagen (HA/COL) scaffold.",

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AU - Parrilla, Claudio

AU - Lattanzi, Wanda

AU - Rita Fetoni, A

AU - Bussu, Francesco

AU - Pola, Enrico

AU - Paludetti, Gaetano

PY - 2010

Y1 - 2010

N2 - Implantation of autologous skin fibroblasts transduced ex vivo with a replication-defective adenoviral vector, carrying the LIM mineralization protein-3 (Ad-LMP-3), and adsorbed on a hydroxyapatite/collagen (HA/COL) scaffold.

AB - Implantation of autologous skin fibroblasts transduced ex vivo with a replication-defective adenoviral vector, carrying the LIM mineralization protein-3 (Ad-LMP-3), and adsorbed on a hydroxyapatite/collagen (HA/COL) scaffold.

KW - Animals

KW - Biocompatible Materials

KW - Bone Regeneration

KW - Collagen

KW - Dermis

KW - Durapatite

KW - Fibroblasts

KW - Gene Therapy

KW - Genetic

KW - Guided Tissue Regeneration

KW - Homeodomain Proteins

KW - LIM-Homeodomain Proteins

KW - Mandible

KW - Osteogenesis

KW - Rats

KW - Tissue Scaffolds

KW - Transcription Factors

KW - Transduction

KW - Wistar

KW - Animals

KW - Biocompatible Materials

KW - Bone Regeneration

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KW - Durapatite

KW - Fibroblasts

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KW - Guided Tissue Regeneration

KW - Homeodomain Proteins

KW - LIM-Homeodomain Proteins

KW - Mandible

KW - Osteogenesis

KW - Rats

KW - Tissue Scaffolds

KW - Transcription Factors

KW - Transduction

KW - Wistar

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ER -

Ex vivo gene therapy using autologous dermal fibroblasts expressing hLMP3 for rat mandibular bone regeneration

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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