Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010.

Manuela Colafigli, Carlo Torti, Enrico Maria Trecarichi, L. Albini, A. Rosi, V. Micheli, N. Manca, G. Penco, B. Bruzzone, G. Punzi, P. Corsi, G. Parruti, P. Bagnarelli, L. Monno, A. Gonnelli, Roberto Cauda, Simona Di Giambenedetto

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral naı ¨ve HIV-1-infected patients, with a genotypic resistance test (GRT) performed £6 months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA
Original languageEnglish
Pages (from-to)299-304
Number of pages6
JournalClinical Microbiology and Infection
DOIs
Publication statusPublished - 2012

Keywords

  • HAART
  • HIV

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