Evolution of HIV-1 tropism at quasispecies level after 5 years of combination antiretroviral therapy in patients always suppressed or experiencing episodes of virological failure

Andrea De Luca, Gabriella Rozera, Isabella Abbate, Emanuela Giombini, Antonella Castagna, Francesca Ceccherini-Silberstein, Alessandro Cozzi Lepri, Giovanni Cassola, Carlo Torti, Antonella D'Arminio Monforte, Giuseppe Ippolito, Maria R. Capobianchi, M. Andreoni, G. Angarano, A. Antinori, F. Castelli, G. Di Perri, M. Galli, A. Lazzarin, P. VialeS. Lo Caputo, C. Mussini, M. Puoti, P. Bonfanti, S. Bonora, A. Gori, G. Lapadula, G. Madeddu, F. Maggiolo, G. Marchetti, L. Monno, E. Quiros Roldan, A. Giacometti, A. Costantini, S. Mazzoccato, C. Santoro, C. Suardi, E. Vanino, G. Verucchi, C. Minardi, T. Quirino, C. Abeli, P. E. Manconi, P. Piano, J. Vecchiet, K. Falasca, L. Sighinolfi, D. Segala, F. Mazzotta, C. Viscoli, A. Alessandrini, R. Piscopo, G. Mazzarello, C. Mastroianni, V. Belvisi, I. Caramma, A. Chiodera, A. P. Castelli, G. Rizzardini, A. L. Ridolfo, R. Piolini, S. Salpietro, L. Carenzi, M. C. Moioli, C. Tincati, C. Puzzolante, N. Abrescia, A. Chirianni, M. G. Guida, M. Gargiulo, F. Baldelli, D. Francisci, G. Parruti, T. Ursini, G. Magnani, M. A. Ursitti, V. Vullo, A. D'Avino, L. Gallo, E. Nicastri, R. Acinapura, M. Capozzi, R. Libertone, G. Tebano, A. Cattelan, L. Sasset, M. S. Mura, B. Rossetti, P. Caramello, G. C. Orofino, M. Sciandra, M. Bassetti, A. Londero, G. Pellizzer, V. Manfrin

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5 Citations (Scopus)

Abstract

Tropism evolution of HIV-1 quasispecies was analysed by ultra-deep pyrosequencing (UDPS) in patients on first-line combination antiretroviral therapy (cART) always suppressed or experiencing virological failure episodes.
Original languageEnglish
Pages (from-to)3085-3094
Number of pages10
JournalJournal of Antimicrobial Chemotherapy
Volume69
DOIs
Publication statusPublished - 2014

Keywords

  • HIV quasispecies
  • cART
  • co-receptor usage
  • tropism switch
  • ultra-deep pyrosequencing

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