Evidence of involvement of leptin and IL-6 peptides in the action of interferon-beta in secondary progressive multiple sclerosis

F Angelucci; Massimiliano Mirabella; Marcella Caggiula; Giovanni Frisullo; Agata Katia Patanella; Cristina Sancricca; Viviana Nociti; Pietro Attilio Tonali; Anna Paola Batocchi

doi:10.1016/j.peptides.2005.03.037

Evidence of involvement of leptin and IL-6 peptides in the action of interferon-beta in secondary progressive multiple sclerosis

F Angelucci, Massimiliano Mirabella, Marcella Caggiula, Giovanni Frisullo, Agata Katia Patanella, Cristina Sancricca, Viviana Nociti, Pietro Attilio Tonali, Anna Paola Batocchi

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Abstract

Leptin is a peptide hormone which acts on cells of immune system by influencing the production of cytokines. Serum leptin levels and cytokine production by peripheral blood mononuclear cells (PBMC) were measured in 18 secondary progressive multiple sclerosis (SPMS) patients under IFN-beta-1b treatment. There were no overall effects on leptin, interleukin-6 (IL-6), IL-10 and IL-12 p40 after 2, 6 and 12 months of treatment. However, leptin and IL-6 decreased after 6 and 12 months of treatment in 12 patients who did not show progression of disability. Thus, our pilot data show that the beneficial effect of IFN-beta on some SPMS patients might be associated with the reduced levels of leptin and reduced IL-6 production by PBMC.

Original language	English
Pages (from-to)	2289-2293
Number of pages	5
Journal	Peptides
Volume	26
DOIs	https://doi.org/10.1016/j.peptides.2005.03.037
Publication status	Published - 2005

Keywords

Interleukin-6
Leptin
Multiple Sclerosis, Chronic Progressive

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10.1016/j.peptides.2005.03.037

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@article{b116e9794de649bd8d8450a48744b858,

title = "Evidence of involvement of leptin and IL-6 peptides in the action of interferon-beta in secondary progressive multiple sclerosis",

abstract = "Leptin is a peptide hormone which acts on cells of immune system by influencing the production of cytokines. Serum leptin levels and cytokine production by peripheral blood mononuclear cells (PBMC) were measured in 18 secondary progressive multiple sclerosis (SPMS) patients under IFN-beta-1b treatment. There were no overall effects on leptin, interleukin-6 (IL-6), IL-10 and IL-12 p40 after 2, 6 and 12 months of treatment. However, leptin and IL-6 decreased after 6 and 12 months of treatment in 12 patients who did not show progression of disability. Thus, our pilot data show that the beneficial effect of IFN-beta on some SPMS patients might be associated with the reduced levels of leptin and reduced IL-6 production by PBMC.",

keywords = "Interleukin-6, Leptin, Multiple Sclerosis, Chronic Progressive, Interleukin-6, Leptin, Multiple Sclerosis, Chronic Progressive",

author = "F Angelucci and Massimiliano Mirabella and Marcella Caggiula and Giovanni Frisullo and Patanella, {Agata Katia} and Cristina Sancricca and Viviana Nociti and Tonali, {Pietro Attilio} and Batocchi, {Anna Paola}",

year = "2005",

doi = "10.1016/j.peptides.2005.03.037",

language = "English",

volume = "26",

pages = "2289--2293",

journal = "Peptides",

issn = "0196-9781",

publisher = "Elsevier Science Incorporated / NY Journals:Madison Square Station, PO Box 882:New York, NY 10159:(212)633-3730, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: (212)633-3680",

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TY - JOUR

T1 - Evidence of involvement of leptin and IL-6 peptides in the action of interferon-beta in secondary progressive multiple sclerosis

AU - Angelucci, F

AU - Mirabella, Massimiliano

AU - Caggiula, Marcella

AU - Frisullo, Giovanni

AU - Patanella, Agata Katia

AU - Sancricca, Cristina

AU - Nociti, Viviana

AU - Tonali, Pietro Attilio

AU - Batocchi, Anna Paola

PY - 2005

Y1 - 2005

N2 - Leptin is a peptide hormone which acts on cells of immune system by influencing the production of cytokines. Serum leptin levels and cytokine production by peripheral blood mononuclear cells (PBMC) were measured in 18 secondary progressive multiple sclerosis (SPMS) patients under IFN-beta-1b treatment. There were no overall effects on leptin, interleukin-6 (IL-6), IL-10 and IL-12 p40 after 2, 6 and 12 months of treatment. However, leptin and IL-6 decreased after 6 and 12 months of treatment in 12 patients who did not show progression of disability. Thus, our pilot data show that the beneficial effect of IFN-beta on some SPMS patients might be associated with the reduced levels of leptin and reduced IL-6 production by PBMC.

AB - Leptin is a peptide hormone which acts on cells of immune system by influencing the production of cytokines. Serum leptin levels and cytokine production by peripheral blood mononuclear cells (PBMC) were measured in 18 secondary progressive multiple sclerosis (SPMS) patients under IFN-beta-1b treatment. There were no overall effects on leptin, interleukin-6 (IL-6), IL-10 and IL-12 p40 after 2, 6 and 12 months of treatment. However, leptin and IL-6 decreased after 6 and 12 months of treatment in 12 patients who did not show progression of disability. Thus, our pilot data show that the beneficial effect of IFN-beta on some SPMS patients might be associated with the reduced levels of leptin and reduced IL-6 production by PBMC.

KW - Interleukin-6

KW - Leptin

KW - Multiple Sclerosis, Chronic Progressive

KW - Interleukin-6

KW - Leptin

KW - Multiple Sclerosis, Chronic Progressive

UR - http://hdl.handle.net/10807/20135

U2 - 10.1016/j.peptides.2005.03.037

DO - 10.1016/j.peptides.2005.03.037

M3 - Article

SN - 0196-9781

VL - 26

SP - 2289

EP - 2293

JO - Peptides

JF - Peptides

ER -

Evidence of involvement of leptin and IL-6 peptides in the action of interferon-beta in secondary progressive multiple sclerosis

Abstract

Keywords

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