Everolimus-induced epithelial to mesenchymal transition in immortalized human renal proximal tubular epithelial cells: key role of heparanase

Giovanni Gambaro, Valentina Masola, Gianluigi Zaza, Simona Granata, Maurizio Onisto, Antonio Lupo

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Everolimus (EVE) is a drug widely used in several renal transplant protocols. Although characterized by a relatively low nephrotoxicity, it may induce several adverse effects including severe fibro-interstitial pneumonitis. The exact molecular/biological mechanism associated to these pro-fibrotic effects is unknown, but epithelial to mesenchymal transition (EMT) may have a central role. Additionally, heparanase, an enzyme recently associated with the progression of chronic allograft nephropathy, could contribute to activate this machinery in renal cells.
Original languageEnglish
Pages (from-to)292-292
Number of pages1
JournalJournal of Translational Medicine
Volume11
DOIs
Publication statusPublished - 2013

Keywords

  • everolimus
  • renal tubular cell

Fingerprint Dive into the research topics of 'Everolimus-induced epithelial to mesenchymal transition in immortalized human renal proximal tubular epithelial cells: key role of heparanase'. Together they form a unique fingerprint.

Cite this