Evaluation of the prevalence of severe hyperhomocysteinemia in adult patients with thrombosis who underwent screening for thrombophilia

Valerio De Stefano, Silvia Betti, Federico Lussana, Armando D'Angelo, Sandra Fedi, Paola Ferrazzi, Cristina Legnani, Rossella Marcucci, Gualtiero Palareti, Lidia L. Rota, Francesca Sampietro, Alessandro Squizzato, Domenico Prisco, Marco Cattaneo

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Treatment with B-vitamins and betaine reduces the high risk of thrombosis in patients with homocystinuria, a metabolic syndrome that is characterized by severe hyperhomocysteinemia (HHcy). In contrast, there is no clear demonstration that B-vitamins reduce the risk of thrombosis in patients with mild HHcy: for this reason, many question the clinical utility of measuring total Hcy (tHcy) in patients with thrombosis. However, thrombosis may be the first clinical manifestation of homocystinuria in patients reaching adulthood without signs and symptoms of the syndrome.
Original languageEnglish
Pages (from-to)681-684
Number of pages4
JournalThrombosis Research
Volume132
DOIs
Publication statusPublished - 2013

Keywords

  • CBS
  • CI
  • Confidence Intervals
  • HHCy
  • Hcy
  • Homocysteine
  • Homocystinuria
  • Hyperhomocysteinemia
  • MTHFR
  • Thrombophilia
  • Thrombosis
  • cystathionine β-synthase
  • homocysteine
  • hyperhomocysteine
  • methylene tethrahydrofolate reductase
  • tHcy
  • total homocysteine

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