Estrogens and androgens affect human luteal cell function

Anna Tropea; Antonio Lanzone; Federica Tiberi; Francesca Romani; Stefania Catino; Rosanna Apa

doi:10.1016/j.fertnstert.2010.02.009

Estrogens and androgens affect human luteal cell function

Anna Tropea
, Antonio Lanzone
, Federica Tiberi
, Francesca Romani
, Stefania Catino
, Rosanna Apa

IRCCS Oasi Maria SS. - Troina (EN)

Research output: Contribution to journal › Article

9 Citations (Scopus)

Abstract

To evaluate estrogens (Es)--E2, estrone (E1), and estriol--and androgens--T and androstendione (A)-effect on P, prostaglandin (PG) F2α, PGE2, and vascular endothelial growth factor (VEGF) release and on VEGF expression in human luteal cells. To elucidate whether androgens effects were direct or mediated by their conversion in Es, an aromatase inhibitor was used. Finally, the luteal effect of the non-aromatizable dihydrotestosterone was evaluated.

Original language	English
Pages (from-to)	2257-2263
Number of pages	7
Journal	Fertility and Sterility
Volume	94
DOIs	https://doi.org/10.1016/j.fertnstert.2010.02.009
Publication status	Published - 2010

Keywords

Adult
Androgens
Aromatase Inhibitors
Cells, Cultured
Dinoprost
Drug Evaluation, Preclinical
Estrogens
Female
Humans
Luteal Cells
Progesterone
Testosterone
Vascular Endothelial Growth Factor A

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10.1016/j.fertnstert.2010.02.009

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title = "Estrogens and androgens affect human luteal cell function",

abstract = "To evaluate estrogens (Es)--E2, estrone (E1), and estriol--and androgens--T and androstendione (A)-effect on P, prostaglandin (PG) F2α, PGE2, and vascular endothelial growth factor (VEGF) release and on VEGF expression in human luteal cells. To elucidate whether androgens effects were direct or mediated by their conversion in Es, an aromatase inhibitor was used. Finally, the luteal effect of the non-aromatizable dihydrotestosterone was evaluated.",

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author = "Anna Tropea and Antonio Lanzone and Federica Tiberi and Francesca Romani and Stefania Catino and Rosanna Apa",

year = "2010",

doi = "10.1016/j.fertnstert.2010.02.009",

language = "English",

volume = "94",

pages = "2257--2263",

journal = "Fertility and Sterility",

issn = "0015-0282",

publisher = "Elsevier Inc.",

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TY - JOUR

T1 - Estrogens and androgens affect human luteal cell function

AU - Tropea, Anna

AU - Lanzone, Antonio

AU - Tiberi, Federica

AU - Romani, Francesca

AU - Catino, Stefania

AU - Apa, Rosanna

PY - 2010

Y1 - 2010

N2 - To evaluate estrogens (Es)--E2, estrone (E1), and estriol--and androgens--T and androstendione (A)-effect on P, prostaglandin (PG) F2α, PGE2, and vascular endothelial growth factor (VEGF) release and on VEGF expression in human luteal cells. To elucidate whether androgens effects were direct or mediated by their conversion in Es, an aromatase inhibitor was used. Finally, the luteal effect of the non-aromatizable dihydrotestosterone was evaluated.

AB - To evaluate estrogens (Es)--E2, estrone (E1), and estriol--and androgens--T and androstendione (A)-effect on P, prostaglandin (PG) F2α, PGE2, and vascular endothelial growth factor (VEGF) release and on VEGF expression in human luteal cells. To elucidate whether androgens effects were direct or mediated by their conversion in Es, an aromatase inhibitor was used. Finally, the luteal effect of the non-aromatizable dihydrotestosterone was evaluated.

KW - Adult

KW - Androgens

KW - Aromatase Inhibitors

KW - Cells, Cultured

KW - Dinoprost

KW - Drug Evaluation, Preclinical

KW - Estrogens

KW - Female

KW - Humans

KW - Luteal Cells

KW - Progesterone

KW - Testosterone

KW - Vascular Endothelial Growth Factor A

KW - Adult

KW - Androgens

KW - Aromatase Inhibitors

KW - Cells, Cultured

KW - Dinoprost

KW - Drug Evaluation, Preclinical

KW - Estrogens

KW - Female

KW - Humans

KW - Luteal Cells

KW - Progesterone

KW - Testosterone

KW - Vascular Endothelial Growth Factor A

UR - http://hdl.handle.net/10807/16808

U2 - 10.1016/j.fertnstert.2010.02.009

DO - 10.1016/j.fertnstert.2010.02.009

M3 - Article

SN - 0015-0282

VL - 94

SP - 2257

EP - 2263

JO - Fertility and Sterility

JF - Fertility and Sterility

ER -

Estrogens and androgens affect human luteal cell function

Abstract

Keywords

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