Epigenetic silencing of SOCS3 identifies a subset of prostate cancer with an aggressive behavior

Francesco Pierconti, Maurizio Martini, Pierfrancesco Bassi, Luigi Maria Larocca, Francesco Pinto, Tonia Cenci, Sara Capodimonti, Alessandro Calarco

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Chronic inflammation and subsequent tissutal alterations may play a key role in prostate carcinogenesis. In this way, molecular alterations of the suppressor of cytokine signaling 3 (SOCS3), one of the most important inhibitory molecule of inflammatory signal transduction circuitries, could contribute to explain the pleiotropic role of interleukin-6 (IL-6) in this type of cancer.
Original languageEnglish
Pages (from-to)318-325
Number of pages8
JournalProstate
Volume71
DOIs
Publication statusPublished - 2011

Keywords

  • Aged
  • Base Sequence
  • DNA Methylation
  • Gene Silencing
  • Humans
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Promoter Regions, Genetic
  • Prostatic Hyperplasia
  • Prostatic Neoplasms
  • Suppressor of Cytokine Signaling Proteins

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