Epidemiologia dell’emofilia a nel mondo e in Italia

Translated title of the contribution: [Autom. eng. transl.] Epidemiology of hemophilia in the world and in Italy

Chiara Cadeddu, Gualtiero Ricciardi, Maria Rosaria Gualano, Antonella Sferrazza, Chiara De Waure, Francesco Di Nardo, Giuseppe La Torre

Research output: Contribution to journalArticle


[Autom. eng. transl.] Haemophilia A is a congenital and hereditary disease, due to a defect in blood coagulation due to the deficiency of factor VIII, whose gene is located on the X chromosome, almost exclusively involving the male sex. The data that the World Federation of Haemophilia collects in 108 countries around the world report about 110,000 prevalent cases of haemophilia A in the world. According to data from the National Registry of Congenital Coagulopathies, in Italy there are about 4,000 subjects suffering from this pathology, half of which is represented by severe hemophilia A and 36% by mild A haemophilia. Regarding the epidemiological evolution of the disease, the nature of the deficit suggests that the incidence of haemophilia A will remain constant, while the improvement in health care levels and the increase in life expectancy of affected patients will increase the number of those who will need anti-hemophilic treatment, due to the increase in prevalence. Moreover, without prejudice to the problem of inhibitor development, the most formidable infectious complications that so many victims have reaped in the 1980s, such as AIDS and viral hepatitis, are disappearing, thanks to better selection of donors and inactivation techniques for viruses to which the products obtained from human blood are subjected and, above all, to the increasingly widespread use of recombinant factors.
Translated title of the contribution[Autom. eng. transl.] Epidemiology of hemophilia in the world and in Italy
Original languageItalian
Pages (from-to)3-16
Number of pages14
JournalItalian Journal of Public Health
Publication statusPublished - 2011


  • Emofilia
  • Epidemiologia
  • Health Technology Assessment


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